6fax: Difference between revisions

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'''Unreleased structure'''


The entry 6fax is ON HOLD until Paper Publication
==Complex of Human CD40 Ectodomain with Lob 7.4 Fab==
 
<StructureSection load='6fax' size='340' side='right' caption='[[6fax]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6fax]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FAX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FAX FirstGlance]. <br>
Description:  
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fax OCA], [http://pdbe.org/6fax PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fax RCSB], [http://www.ebi.ac.uk/pdbsum/6fax PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fax ProSAT]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/TNR5_HUMAN TNR5_HUMAN]] Defects in CD40 are the cause of immunodeficiency with hyper-IgM type 3 (HIGM3) [MIM:[http://omim.org/entry/606843 606843]]. A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.<ref>PMID:11675497</ref>  
== Function ==
[[http://www.uniprot.org/uniprot/TNR5_HUMAN TNR5_HUMAN]] Receptor for TNFSF5/CD40LG.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Orr, C M]]
[[Category: Pearson, A R]]
[[Category: Tews, I]]
[[Category: Agonist]]
[[Category: Cd40]]
[[Category: Engineered fab]]
[[Category: Immune system]]
[[Category: Mab]]

Revision as of 09:24, 7 February 2018

Complex of Human CD40 Ectodomain with Lob 7.4 FabComplex of Human CD40 Ectodomain with Lob 7.4 Fab

Structural highlights

6fax is a 3 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[TNR5_HUMAN] Defects in CD40 are the cause of immunodeficiency with hyper-IgM type 3 (HIGM3) [MIM:606843]. A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.[1]

Function

[TNR5_HUMAN] Receptor for TNFSF5/CD40LG.

References

  1. ↑ Ferrari S, Giliani S, Insalaco A, Al-Ghonaium A, Soresina AR, Loubser M, Avanzini MA, Marconi M, Badolato R, Ugazio AG, Levy Y, Catalan N, Durandy A, Tbakhi A, Notarangelo LD, Plebani A. Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12614-9. PMID:11675497 doi:10.1073/pnas.221456898

6fax, resolution 2.99Å

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