6bf6: Difference between revisions

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'''Unreleased structure'''


The entry 6bf6 is ON HOLD
==Cryo-EM structure of human insulin degrading enzyme==
 
<StructureSection load='6bf6' size='340' side='right' caption='[[6bf6]], [[Resolution|resolution]] 6.50&Aring;' scene=''>
Authors: Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6bf6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BF6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BF6 FirstGlance]. <br>
Description: Cryo-EM structure of human insulin degrading enzyme
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6b70|6b70]], [[6b3q|6b3q]], [[6b7y|6b7y]], [[6b7z|6b7z]]</td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr>
[[Category: Tan, Y.Z]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bf6 OCA], [http://pdbe.org/6bf6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bf6 RCSB], [http://www.ebi.ac.uk/pdbsum/6bf6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bf6 ProSAT]</span></td></tr>
[[Category: Kossiakoff, A.A]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Insulysin]]
[[Category: Bailey, L J]]
[[Category: Carragher, B]]
[[Category: Carragher, B]]
[[Category: Kossiakoff, A A]]
[[Category: Liang, W G]]
[[Category: Potter, S C]]
[[Category: Tan, Y Z]]
[[Category: Tang, W J]]
[[Category: Wei, H]]
[[Category: Zhang, Z]]
[[Category: Zhang, Z]]
[[Category: Wei, H]]
[[Category: Amyloid beta]]
[[Category: Liang, W.G]]
[[Category: Hydrolase]]
[[Category: Bailey, L.J]]
[[Category: Ide]]
[[Category: Potter, S.C]]
[[Category: Tang, W.J]]

Revision as of 09:19, 7 February 2018

Cryo-EM structure of human insulin degrading enzymeCryo-EM structure of human insulin degrading enzyme

Structural highlights

6bf6 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Activity:Insulysin, with EC number 3.4.24.56
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.[1] [2] [3]

References

  1. ↑ Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci. 2000 Mar 1;20(5):1657-65. PMID:10684867
  2. ↑ Im H, Manolopoulou M, Malito E, Shen Y, Zhao J, Neant-Fery M, Sun CY, Meredith SC, Sisodia SS, Leissring MA, Tang WJ. Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. J Biol Chem. 2007 Aug 31;282(35):25453-63. Epub 2007 Jul 5. PMID:17613531 doi:10.1074/jbc.M701590200
  3. ↑ Malito E, Ralat LA, Manolopoulou M, Tsay JL, Wadlington NL, Tang WJ. Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme. Biochemistry. 2008 Nov 6. PMID:18986166 doi:10.1021/bi801192h

6bf6, resolution 6.50Å

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