4kk2: Difference between revisions

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[[Category: Bhosle, R]]
[[Category: Bhosle, R]]
[[Category: Chowdhury, S]]
[[Category: Chowdhury, S]]
[[Category: EFI, Enzyme Function Initiative]]
[[Category: Evans, B]]
[[Category: Evans, B]]
[[Category: Gerlt, J A]]
[[Category: Gerlt, J A]]
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[[Category: Hillerich, B]]
[[Category: Hillerich, B]]
[[Category: Imker, H J]]
[[Category: Imker, H J]]
[[Category: Initiative, Enzyme Function]]
[[Category: Love, J]]
[[Category: Love, J]]
[[Category: Obaidi, N F.Al]]
[[Category: Obaidi, N F.Al]]

Revision as of 09:47, 31 January 2018

Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structureCrystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure

Structural highlights

4kk2 is a 2 chain structure with sequence from Artsi. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:FDS-5, FDS-1 (ARTSI)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CHRDS_ARTSI] Condenses two molecules of dimethylallyl diphosphate (DMAPP) to produce mainly an irregular monoterpene, chrysanthemyl diphosphate (CPP) and lower amounts of a branched monoterpene, lavandulyl diphosphate (LPP). CPP is a precursor of the pyrethrin insecticides. When incubated with isopentenyl diphosphate (IPP) and DMAPP, catalyzes three competing isoprenoid condensation reactions, a chain elongation to give geranyl diphosphate (GPP), a cyclopropanation to give CPP and a branching to give LPP.[1]

References

  1. Hemmerlin A, Rivera SB, Erickson HK, Poulter CD. Enzymes encoded by the farnesyl diphosphate synthase gene family in the Big Sagebrush Artemisia tridentata ssp. spiciformis. J Biol Chem. 2003 Aug 22;278(34):32132-40. Epub 2003 Jun 2. PMID:12782626 doi:10.1074/jbc.M213045200

4kk2, resolution 2.20Å

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OCA