5msb: Difference between revisions

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-'''Unreleased structure'''
-The entry 5msb is ON HOLD  until Paper Publication
+==Crystal structure of human carbonic anhydrase isozyme XII with 2,3,5,6-tetrafluoro-4[(2-hydroxyethyl)sulfonyl]benzenesulfonamide==
+<StructureSection load='5msb' size='340' side='right' caption='[[5msb]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
-Authors: Smirnov, A., Manakova, E., Grazulis, S.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5msb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MSB FirstGlance]. <br>
-Description: Crystal structure of human carbonic anhydrase isozyme XII with 2,3,5,6-tetrafluoro-4[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=V13:2,3,5,6-TETRAFLUORO-4-[(2-HYDROXYETHYL)SULFONYL]BENZENESULFONAMIDE'>V13</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5llc|5llc]], [[5lle|5lle]], [[5llg|5llg]], [[5llh|5llh]], [[5lln|5lln]], [[5llo|5llo]], [[5llp|5llp]], [[5msa|5msa]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5msb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5msb OCA], [http://pdbe.org/5msb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5msb RCSB], [http://www.ebi.ac.uk/pdbsum/5msb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5msb ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/CAH12_HUMAN CAH12_HUMAN]] Defects in CA12 are the cause of hyperchlorhidrosis isolated (HCHLH) [MIM:[http://omim.org/entry/143860 143860]]. HCHLH is a disorder characterized by excessive sweating and increased sweat chloride levels. Affected individuals suffer from episodes of hyponatremic dehydration and report increased amounts of visible salt precipitates in sweat.<ref>PMID:21035102</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/CAH12_HUMAN CAH12_HUMAN]] Reversible hydration of carbon dioxide.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Carbonate dehydratase]]
+[[Category: Grazulis, S]]
 [[Category: Manakova, E]]
-[[Category: Grazulis, S]]
 [[Category: Smirnov, A]]
+[[Category: Benzenesulfonamide]]
+[[Category: Carbonic anhydrase]]
+[[Category: Drug design]]
+[[Category: Lyase]]
+[[Category: Lyase-lyase inhibitor complex]]
+[[Category: Metal-binding]]