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==Extended E2 DNA-binding domain of the Bovine Papillomavirus-1== | |||
<StructureSection load='6bus' size='340' side='right' caption='[[6bus]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6bus]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BUS FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bus OCA], [http://pdbe.org/6bus PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bus RCSB], [http://www.ebi.ac.uk/pdbsum/6bus PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bus ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
[[Category: Leroy, L | == Function == | ||
[[Category: | [[http://www.uniprot.org/uniprot/VE2_BPV1 VE2_BPV1]] E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication. | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Barbosa, J A.R G]] | |||
[[Category: Leroy, L M.D]] | |||
[[Category: Pinheiro, C B]] | |||
[[Category: Polikarpov, I]] | [[Category: Polikarpov, I]] | ||
[[Category: | [[Category: Bpv-1]] | ||
[[Category: Dna binding protein]] | |||
[[Category: E2]] | |||
[[Category: Open reading frame]] | |||
Revision as of 11:32, 10 January 2018
Extended E2 DNA-binding domain of the Bovine Papillomavirus-1Extended E2 DNA-binding domain of the Bovine Papillomavirus-1
Structural highlights
Function[VE2_BPV1] E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication. |
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