5oec: Difference between revisions

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'''Unreleased structure'''


The entry 5oec is ON HOLD  until Paper Publication
==Human Rab32 (18-201):GDP in complex with Salmonella GtgE (21-214) C45A mutant==
 
<StructureSection load='5oec' size='340' side='right' caption='[[5oec]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
Authors: Wachtel, R., Braeuning, B., Mader, S.L., Ecker, F., Kaila, V.R.I., Groll, M., Itzen, A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5oec]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OEC FirstGlance]. <br>
Description: Human Rab32 (18-201):GDP in complex with Salmonella GtgE (21-214) C45A mutant
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cym|4cym]], [[4mi7|4mi7]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oec OCA], [http://pdbe.org/5oec PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oec RCSB], [http://www.ebi.ac.uk/pdbsum/5oec PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oec ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/RAB32_HUMAN RAB32_HUMAN]] Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.<ref>PMID:12186851</ref> <ref>PMID:21255211</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Braeuning, B]]
[[Category: Ecker, F]]
[[Category: Groll, M]]
[[Category: Groll, M]]
[[Category: Braeuning, B]]
[[Category: Itzen, A]]
[[Category: Kaila, V R.I]]
[[Category: Mader, S L]]
[[Category: Wachtel, R]]
[[Category: Wachtel, R]]
[[Category: Kaila, V.R.I]]
[[Category: Hydrolase]]
[[Category: Itzen, A]]
[[Category: Posttranslational modification]]
[[Category: Mader, S.L]]
[[Category: Proteolysis]]
[[Category: Ecker, F]]
[[Category: Rab gtpase]]
[[Category: Salmonella infection]]

Revision as of 11:22, 10 January 2018

Human Rab32 (18-201):GDP in complex with Salmonella GtgE (21-214) C45A mutantHuman Rab32 (18-201):GDP in complex with Salmonella GtgE (21-214) C45A mutant

Structural highlights

5oec is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
NonStd Res:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[RAB32_HUMAN] Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.[1] [2]

References

  1. ↑ Alto NM, Soderling J, Scott JD. Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics. J Cell Biol. 2002 Aug 19;158(4):659-68. Epub 2002 Aug 19. PMID:12186851 doi:http://dx.doi.org/10.1083/jcb.200204081
  2. ↑ Seto S, Tsujimura K, Koide Y. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. Traffic. 2011 Apr;12(4):407-20. doi: 10.1111/j.1600-0854.2011.01165.x. Epub 2011 , Feb 21. PMID:21255211 doi:10.1111/j.1600-0854.2011.01165.x

5oec, resolution 2.30Å

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