Insulin-Degrading Enzyme: Difference between revisions
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<StructureSection load=' | <StructureSection load='' size='350' side='right' scene='42/428052/Cv/1' caption='Human insulin-degrading enzyme (grey and green) complex with glucagon preproprotein peptide (pink and yellow) and diethylene dioxide (PDB code [[2g49]])'> | ||
== Function == | == Function == | ||
[[Insulin-Degrading Enzyme]] (PDB entry [[2g49]]) is a highly conserved 2*113 kDa homodimeric zinc metalloprotease. It belongs to the M16A family of metalloproteases within the ME clan. It hydrolyses insulin and several amyloidogenic peptides like amyloid-β (Aβ). | [[Insulin-Degrading Enzyme]] (PDB entry [[2g49]]) is a highly conserved 2*113 kDa homodimeric zinc metalloprotease. It belongs to the M16A family of metalloproteases within the ME clan. It hydrolyses insulin and several amyloidogenic peptides like amyloid-β (Aβ). | ||