6ev3: Difference between revisions

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<StructureSection load='6ev3' size='340' side='right' caption='[[6ev3]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
<StructureSection load='6ev3' size='340' side='right' caption='[[6ev3]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6ev3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EV3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6ev3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/A._niger A. niger]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EV3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4LU:1-DEOXY-5-O-PHOSPHONO-1-(3,3,4,5-TETRAMETHYL-9,11-DIOXO-2,3,8,9,10,11-HEXAHYDRO-7H-QUINOLINO[1,8-FG]PTERIDIN-12-IUM-7-YL)-D-RIBITOL'>4LU</scene>, <scene name='pdbligand=FZZ:1-DEOXY-5-O-PHOSPHONO-1-[(10AR)-2,2,3,4-TETRAMETHYL-8,10-DIOXO-1,2,8,9,10,10A-HEXAHYDRO-6H-INDENO[1,7-EF]PYRIMIDO[4,5-B][1,4]DIAZEPIN-6-YL]-D-RIBITOL'>FZZ</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4LU:1-DEOXY-5-O-PHOSPHONO-1-(3,3,4,5-TETRAMETHYL-9,11-DIOXO-2,3,8,9,10,11-HEXAHYDRO-7H-QUINOLINO[1,8-FG]PTERIDIN-12-IUM-7-YL)-D-RIBITOL'>4LU</scene>, <scene name='pdbligand=FZZ:1-DEOXY-5-O-PHOSPHONO-1-[(10AR)-2,2,3,4-TETRAMETHYL-8,10-DIOXO-1,2,8,9,10,10A-HEXAHYDRO-6H-INDENO[1,7-EF]PYRIMIDO[4,5-B][1,4]DIAZEPIN-6-YL]-D-RIBITOL'>FZZ</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fdc1, An03g06590 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5061 A. niger])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenacrylate_decarboxylase Phenacrylate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.102 4.1.1.102] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenacrylate_decarboxylase Phenacrylate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.102 4.1.1.102] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ev3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ev3 OCA], [http://pdbe.org/6ev3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ev3 RCSB], [http://www.ebi.ac.uk/pdbsum/6ev3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ev3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ev3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ev3 OCA], [http://pdbe.org/6ev3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ev3 RCSB], [http://www.ebi.ac.uk/pdbsum/6ev3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ev3 ProSAT]</span></td></tr>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: A. niger]]
[[Category: Phenacrylate decarboxylase]]
[[Category: Phenacrylate decarboxylase]]
[[Category: Bailey, S S]]
[[Category: Bailey, S S]]

Revision as of 12:01, 27 December 2017

Structure of wild type A. niger Fdc1 that has been illuminated with UV light, with prFMN in the iminium and ketimine formStructure of wild type A. niger Fdc1 that has been illuminated with UV light, with prFMN in the iminium and ketimine form

Structural highlights

6ev3 is a 1 chain structure with sequence from A. niger. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , ,
Gene:fdc1, An03g06590 (A. niger)
Activity:Phenacrylate decarboxylase, with EC number 4.1.1.102
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[FDC1_ASPNC] Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.[HAMAP-Rule:MF_03196][1]

References

  1. ↑ Payne KA, White MD, Fisher K, Khara B, Bailey SS, Parker D, Rattray NJ, Trivedi DK, Goodacre R, Beveridge R, Barran P, Rigby SE, Scrutton NS, Hay S, Leys D. New cofactor supports alpha,beta-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition. Nature. 2015 Jun 25;522(7557):497-501. doi: 10.1038/nature14560. Epub 2015 Jun, 17. PMID:26083754 doi:http://dx.doi.org/10.1038/nature14560

6ev3, resolution 1.30Å

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