6eva: Difference between revisions

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'''Unreleased structure'''


The entry 6eva is ON HOLD  until Paper Publication
==Structure of E277Q A. niger fdc1 in complex with a phenylpyruvate derived adduct to the prenylated flavin cofactor==
 
<StructureSection load='6eva' size='340' side='right' caption='[[6eva]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
Authors: Bailey, S.S., David, L., Payne, K.A.P.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6eva]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EVA FirstGlance]. <br>
Description: Structure of E277Q A. niger fdc1 in complex with a phenylpyruvate derived adduct to the prenylated flavin cofactor
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4MJ:1-DEOXY-5-O-PHOSPHONO-1-[(1S)-3,3,4,5-TETRAMETHYL-9,11-DIOXO-1-(PHENYLACETYL)-2,3,8,9,10,11-HEXAHYDRO-1H,7H-QUINOLINO[1,8-FG]PTERIDIN-7-YL]-D-RIBITOL'>4MJ</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenacrylate_decarboxylase Phenacrylate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.102 4.1.1.102] </span></td></tr>
[[Category: Payne, K.A.P]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eva OCA], [http://pdbe.org/6eva PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eva RCSB], [http://www.ebi.ac.uk/pdbsum/6eva PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eva ProSAT]</span></td></tr>
[[Category: Bailey, S.S]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/FDC1_ASPNC FDC1_ASPNC]] Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.[HAMAP-Rule:MF_03196]<ref>PMID:26083754</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Phenacrylate decarboxylase]]
[[Category: Bailey, S S]]
[[Category: David, L]]
[[Category: David, L]]
[[Category: Payne, K A.P]]
[[Category: Lyase]]

Revision as of 09:28, 20 December 2017

Structure of E277Q A. niger fdc1 in complex with a phenylpyruvate derived adduct to the prenylated flavin cofactorStructure of E277Q A. niger fdc1 in complex with a phenylpyruvate derived adduct to the prenylated flavin cofactor

Structural highlights

6eva is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Activity:Phenacrylate decarboxylase, with EC number 4.1.1.102
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[FDC1_ASPNC] Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.[HAMAP-Rule:MF_03196][1]

References

  1. ↑ Payne KA, White MD, Fisher K, Khara B, Bailey SS, Parker D, Rattray NJ, Trivedi DK, Goodacre R, Beveridge R, Barran P, Rigby SE, Scrutton NS, Hay S, Leys D. New cofactor supports alpha,beta-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition. Nature. 2015 Jun 25;522(7557):497-501. doi: 10.1038/nature14560. Epub 2015 Jun, 17. PMID:26083754 doi:http://dx.doi.org/10.1038/nature14560

6eva, resolution 1.64Å

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