1sch

File:1sch.gif

spinqualitylabelsall models 1sch, resolution 2.56Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

PEANUT PEROXIDASE

OverviewOverview

BACKGROUND. Peroxidases catalyze a wide variety of peroxide-dependent, oxidations. Based on sequence alignments, heme peroxidases have been, divided into three classes. Crystal structures are available for, peroxidases of classes I and II, but until now no structure has been, determined for class III, the classical extracellular plant peroxidases., RESULTS. The crystal structure of peanut peroxidase has been solved to 2.7, A resolution. The helical fold is similar to that of known peroxidase, structures. The 294-residue polypeptide chain is accompanied by a heme and, two calcium ions, and there is some evidence of glycosylation., CONCLUSIONS. This is the first complete structure of a class III, peroxidase and as such should serve as a model for other class III enzymes, including the much-studied horseradish peroxidase. It may also aid in the, interpretation of functional differences between the peroxidase classes., Ten helices conserved in class I and II peroxidases are also found in, peanut peroxidase. Key residues of the heme environment and the location, of two calcium ions are shared with class II peroxidases. Peanut, peroxidase contains three unique helices, two of which contribute to the, substrate access channel leading to the heme edge.

About this StructureAbout this Structure

1SCH is a Single protein structure of sequence from Arachis hypogaea with NAG, CA and HEM as ligands. Active as Peroxidase, with EC number 1.11.1.7 Structure known Active Sites: ADC, ADH, APC, APH, BDC, BDH, BPC and BPH. Full crystallographic information is available from OCA.

ReferenceReference

The crystal structure of peanut peroxidase., Schuller DJ, Ban N, Huystee RB, McPherson A, Poulos TL, Structure. 1996 Mar 15;4(3):311-21. PMID:8805539

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