4boe: Difference between revisions
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<StructureSection load='4boe' size='340' side='right' caption='[[4boe]], [[Resolution|resolution]] 2.24Å' scene=''> | <StructureSection load='4boe' size='340' side='right' caption='[[4boe]], [[Resolution|resolution]] 2.24Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4boe]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BOE FirstGlance]. <br> | <table><tr><td colspan='2'>[[4boe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brown_ear_tick Brown ear tick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BOE FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand= | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4boe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4boe OCA], [http://pdbe.org/4boe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4boe RCSB], [http://www.ebi.ac.uk/pdbsum/4boe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4boe ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4boe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4boe OCA], [http://pdbe.org/4boe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4boe RCSB], [http://www.ebi.ac.uk/pdbsum/4boe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4boe ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Two crystal structures of Japanin, an 18 kDa immune-modulatory lipocalin from the Brown Ear Tick (Rhipicephalus appendiculatus), have been determined at 2.2 and 2.4 A resolution. In both crystal forms the protein is in complex with cholesterol, which sits in a closed pocket at the centre of the lipocalin barrel. Both crystal forms are dimers, which are also observed in solution. Molecular modelling suggests that previously-described members of a tick protein family bearing high sequence homology to Japanin are also likely to bind cholesterol or cholesterol derivatives. | |||
Structural basis of cholesterol binding by a novel clade of dendritic cell modulators from ticks.,Roversi P, Johnson S, Preston SG, Nunn MA, Paesen GC, Austyn JM, Nuttall PA, Lea SM Sci Rep. 2017 Nov 22;7(1):16057. doi: 10.1038/s41598-017-16413-2. PMID:29167574<ref>PMID:29167574</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4boe" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Brown ear tick]] | |||
[[Category: Austyn, J M]] | [[Category: Austyn, J M]] | ||
[[Category: Johnson, S]] | [[Category: Johnson, S]] | ||
Revision as of 10:19, 13 December 2017
Japanin from Rhipicephalus appendiculatus bound to cholesterol: Tetragonal crystal formJapanin from Rhipicephalus appendiculatus bound to cholesterol: Tetragonal crystal form
Structural highlights
Publication Abstract from PubMedTwo crystal structures of Japanin, an 18 kDa immune-modulatory lipocalin from the Brown Ear Tick (Rhipicephalus appendiculatus), have been determined at 2.2 and 2.4 A resolution. In both crystal forms the protein is in complex with cholesterol, which sits in a closed pocket at the centre of the lipocalin barrel. Both crystal forms are dimers, which are also observed in solution. Molecular modelling suggests that previously-described members of a tick protein family bearing high sequence homology to Japanin are also likely to bind cholesterol or cholesterol derivatives. Structural basis of cholesterol binding by a novel clade of dendritic cell modulators from ticks.,Roversi P, Johnson S, Preston SG, Nunn MA, Paesen GC, Austyn JM, Nuttall PA, Lea SM Sci Rep. 2017 Nov 22;7(1):16057. doi: 10.1038/s41598-017-16413-2. PMID:29167574[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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