6bqq: Difference between revisions

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-'''Unreleased structure'''
-The entry 6bqq is ON HOLD
+==Crystal Structure of the Human CAMKK2B in complex with BI2526==
+<StructureSection load='6bqq' size='340' side='right' caption='[[6bqq]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-Authors: Counago, R.M., de Souza, G.P., dos Reis, C.V., Ramos, P.Z., Drewry, D., Massirer, K.B., Arruda, P., Edwards, A.M., Elkins, J.M., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6bqq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQQ FirstGlance]. <br>
-Description: Crystal Structure of the Human CAMKK2B in complex with BI2526
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=R78:4-{[(7R)-8-CYCLOPENTYL-7-ETHYL-5-METHYL-6-OXO-5,6,7,8-TETRAHYDROPTERIDIN-2-YL]AMINO}-3-METHOXY-N-(1-METHYLPIPERIDIN-4-YL)BENZAMIDE'>R78</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
-[[Category: Elkins, J.M]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqq OCA], [http://pdbe.org/6bqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bqq RCSB], [http://www.ebi.ac.uk/pdbsum/6bqq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqq ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KKCC2_HUMAN KKCC2_HUMAN]] Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.<ref>PMID:11395482</ref> <ref>PMID:12935886</ref> <ref>PMID:9662074</ref> <ref>PMID:21957496</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Calcium/calmodulin-dependent protein kinase]]
+[[Category: Arruda, P]]
+[[Category: Counago, R M]]
 [[Category: Drewry, D]]
-[[Category: Edwards, A.M]]
+[[Category: Edwards, A M]]
-[[Category: Arruda, P]]
+[[Category: Elkins, J M]]
-[[Category: Structural Genomics Consortium (Sgc)]]
+[[Category: Massirer, K B]]
-[[Category: Massirer, K.B]]
+[[Category: Ramos, P Z]]
-[[Category: Ramos, P.Z]]
+[[Category: Reis, C V.dos]]
-[[Category: Counago, R.M]]
+[[Category: Structural genomic]]
-[[Category: Dos Reis, C.V]]
+[[Category: Souza, G P.de]]
-[[Category: De Souza, G.P]]
+[[Category: Protein kinase domain]]
+[[Category: Sgc]]
+[[Category: Transferase]]
+[[Category: Transferase inhibitor complex]]