Ectonucleotide pyrophosphatase/phosphodiesterase: Difference between revisions
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Michal Harel (talk | contribs) New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Ectonucleotide pyrophosphatase/phosphodiesterase''' family of pro... |
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
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*'''Ectonucleotide pyrophosphatase/phosphodiesterase 4''' or (ENPP4) is an extracellular membrane protein which hydrolyzes adenine dinucleotide Ap3A thus causing platelet aggregation<ref>PMID:24338010</ref><br />. | *'''Ectonucleotide pyrophosphatase/phosphodiesterase 4''' or (ENPP4) is an extracellular membrane protein which hydrolyzes adenine dinucleotide Ap3A thus causing platelet aggregation<ref>PMID:24338010</ref><br />. | ||
*'''Ectonucleotide pyrophosphatase/phosphodiesterase 6''' (ENPP6) hydrolyzes choline-containing compounds like lysophosphatidylcholine<ref>PMID:23161088</ref><br />. | *'''Ectonucleotide pyrophosphatase/phosphodiesterase 6''' (ENPP6) hydrolyzes choline-containing compounds like lysophosphatidylcholine<ref>PMID:23161088</ref><br />. | ||
*'''Ectonucleotide pyrophosphatase/phosphodiesterase 7''' or '''alkaline sphingomyelinase''' (ENPP7) converts sphingomyelin into ceramide and phosphocholine<ref>PMID: | *'''Ectonucleotide pyrophosphatase/phosphodiesterase 7''' or '''alkaline sphingomyelinase''' (ENPP7) converts sphingomyelin into ceramide and phosphocholine<ref>PMID:28292932</ref><br />. | ||
== Disease == | == Disease == | ||
Revision as of 14:53, 12 December 2017
FunctionEctonucleotide pyrophosphatase/phosphodiesterase family of proteins mediates purinergic signaling by degrading extracellular nucleotides and also participate in phospholipid metabolism[1]
DiseaseRelevanceEPPN7 may protect the intestinal mucosa from inflammation and tumorigenesis. Structural highlights |
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3D Structures of ectonucleotide pyrophosphatase/phosphodiesterase3D Structures of ectonucleotide pyrophosphatase/phosphodiesterase
Updated on 12-December-2017
ReferencesReferences
- ↑ Gorelik A, Randriamihaja A, Illes K, Nagar B. A Key Tyrosine Substitution Restricts Nucleotide Hydrolysis by the Ectoenzyme NPP5. FEBS J. 2017 Sep 12. doi: 10.1111/febs.14266. PMID:28898552 doi:http://dx.doi.org/10.1111/febs.14266
- ↑ Jansen S, Perrakis A, Ulens C, Winkler C, Andries M, Joosten RP, Van Acker M, Luyten FP, Moolenaar WH, Bollen M. Structure of NPP1, an Ectonucleotide Pyrophosphatase/Phosphodiesterase Involved in Tissue Calcification. Structure. 2012 Oct 2. pii: S0969-2126(12)00330-9. doi:, 10.1016/j.str.2012.09.001. PMID:23041369 doi:http://dx.doi.org/10.1016/j.str.2012.09.001
- ↑ Nam HK, Liu J, Li Y, Kragor A, Hatch NE. Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) protein regulates osteoblast differentiation. J Biol Chem. 2011 Nov 11;286(45):39059-71. doi: 10.1074/jbc.M111.221689. Epub, 2011 Sep 19. PMID:21930712 doi:http://dx.doi.org/10.1074/jbc.M111.221689
- ↑ Jansen S, Perrakis A, Ulens C, Winkler C, Andries M, Joosten RP, Van Acker M, Luyten FP, Moolenaar WH, Bollen M. Structure of NPP1, an Ectonucleotide Pyrophosphatase/Phosphodiesterase Involved in Tissue Calcification. Structure. 2012 Oct 2. pii: S0969-2126(12)00330-9. doi:, 10.1016/j.str.2012.09.001. PMID:23041369 doi:http://dx.doi.org/10.1016/j.str.2012.09.001
- ↑ Albright RA, Ornstein DL, Cao W, Chang WC, Robert D, Tehan M, Hoyer D, Liu L, Stabach P, Yang G, De La Cruz EM, Braddock DT. Molecular basis of purinergic signal metabolism by ectonucleotide pyrophosphatase/phosphodiesterases 4 and 1 and implications in stroke. J Biol Chem. 2014 Feb 7;289(6):3294-306. doi: 10.1074/jbc.M113.505867. Epub 2013 , Dec 12. PMID:24338010 doi:http://dx.doi.org/10.1074/jbc.M113.505867
- ↑ Greiner-Tollersrud L, Berg T, Stensland HM, Evjen G, Greiner-Tollersrud OK. Bovine brain myelin glycerophosphocholine choline phosphodiesterase is an alkaline lysosphingomyelinase of the eNPP-family, regulated by lysosomal sorting. Neurochem Res. 2013 Feb;38(2):300-10. doi: 10.1007/s11064-012-0921-z. Epub 2012, Nov 17. PMID:23161088 doi:http://dx.doi.org/10.1007/s11064-012-0921-z
- ↑ Gorelik A, Liu F, Illes K, Nagar B. Crystal Structure of the Human Alkaline Sphingomyelinase Provides Insights into Substrate Recognition. J Biol Chem. 2017 Mar 14. pii: jbc.M116.769273. doi: 10.1074/jbc.M116.769273. PMID:28292932 doi:http://dx.doi.org/10.1074/jbc.M116.769273