Sandbox Reserved 1063: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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 === Binding Site 2 ===
-<scene name='69/694230/Binding_site_2/4'>Binding site 2</scene> consists of a highly distorted tetrahedral geometry around the zinc ion. There are three amino acids involved in the binding of the zinc ion (C30, E41, and E107) as well as a water molecule (shown as a red sphere). If Cys30 in binding site 2 is mutated to an alanine, it will have no effect on the ability of the protein to bind DNA <ref name="guerra" />. Therefore, binding site 2 has no significant role in the ability of AdcR to bind to DNA and AdcR is still able to function with no zinc bound present in binding site 2. In fact, the presence of binding site 2 may simply be due to an excess of zinc during the crystallization process.
+<scene name='69/694230/Binding_site_2/4'>Binding site 2</scene> consists of a highly distorted tetrahedral geometry around the zinc ion. There are three amino acids involved in the binding of the zinc ion (C30, E41, and E107) as well as a water molecule (shown as a red sphere). When Cys30 in binding site 2 is mutated to an alanine, it has no effect on the ability of the protein to bind DNA <ref name="guerra" />. Therefore, binding site 2 has no significant role in the ability of AdcR to bind to DNA and AdcR is still able to function with no zinc bound present in binding site 2. In fact, the presence of binding site 2 may simply be due to an excess of zinc during the crystallization process.
 === Hydrogen Bond Network ===