Sandbox Reserved 1063: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA, Zach LaRoche, Paxton Schowe, Geoffrey C. Hoops, Alexi Zaniker, Shandeep Singh, Isaac C. Gluesenkamp

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 <StructureSection load='3TGN' size='350' side='right' caption='[http://www.rcsb.org/pdb/explore/explore.do?structureId=3TGN Adhesin Competence Regulator (3TGN)]' scene=''>
 ===Introduction===
-Adhesin Competence Regulator (<scene name='69/694230/Adcr_space_fill/1'>AdcR</scene>) is a transcriptional regulator that controls the activation of over seventy genes within the bacterium [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae''Streptococcus pneumoniae''] and is a member of the multiple antibiotic resistance regulator (MarR) protein family <ref name="Sanson">DOI:10.1093/nar/gku1304 </ref>. Members of the Mar R <ref> PMID: 23428319</ref> protein family conserve a number of features including a general triangular shape, a two fold pseudosymmetric homodimer, and a winged helix-turn-helix pattern [https://en.wikipedia.org/wiki/Helix-turn-helix (wHTH)] which can be seen in Figure 1. AdcR exhibits these conserved features as well, while also exhibiting its own distinct features.
+Adhesin Competence Regulator (<scene name='69/694230/Adcr_space_fill/1'>AdcR</scene>) is a transcriptional regulator that controls the activation of over seventy genes within the bacterium [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae''Streptococcus pneumoniae''] <ref name="Sanson">DOI:10.1093/nar/gku1304 </ref> and is a member of the multiple antibiotic resistance regulator (MarR) protein family . Members of the Mar R protein family <ref> PMID: 23428319</ref> conserve a number of features including a general triangular shape, a two fold pseudosymmetric homodimer, and a winged helix-turn-helix pattern [https://en.wikipedia.org/wiki/Helix-turn-helix (wHTH)] which can be seen in Figure 1. AdcR exhibits these conserved features as well, while also exhibiting its own distinct features.
 [[Image:MarR_protein_family_slide.png|500px|left|thumb|'''Figure 1'''. Proteins MarR [http://www.rcsb.org/pdb/explore/explore.do?structureId=3bpx (3BPX)], HucR [http://www.rcsb.org/pdb/explore/explore.do?structureId=2FBK (2FBK)], TcaR [http://www.rcsb.org/pdb/explore/explore.do?structureId=3KP5 (3KP5)], and OhrR [http://www.rcsb.org/pdb/explore/explore.do?structureId=2pfb (2PFB)] are pictured above with conserved features of the MarR protein family highlighted]]