2bto: Difference between revisions
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bto OCA], [http://www.ebi.ac.uk/pdbsum/2bto PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bto RCSB]</span> | |||
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[[Category: Lowe, J.]] | [[Category: Lowe, J.]] | ||
[[Category: Schlieper, D.]] | [[Category: Schlieper, D.]] | ||
[[Category: bacterial tubulin]] | [[Category: bacterial tubulin]] | ||
[[Category: cytoskeletal protein]] | [[Category: cytoskeletal protein]] | ||
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[[Category: protein complex]] | [[Category: protein complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:11:34 2008'' | ||
Revision as of 02:11, 31 March 2008
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| , resolution 2.50Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF BTUBA FROM PROSTHECOBACTER DEJONGEII
OverviewOverview
alphabeta-Tubulin heterodimers, from which the microtubules of the cytoskeleton are built, have a complex chaperone-dependent folding pathway. They are thought to be unique to eukaryotes, whereas the homologue FtsZ can be found in bacteria. The exceptions are BtubA and BtubB from Prosthecobacter, which have higher sequence homology to eukaryotic tubulin than to FtsZ. Here we show that some of their properties are different from tubulin, such as weak dimerization and chaperone-independent folding. However, their structure is strikingly similar to tubulin including surface loops, and BtubA/B form tubulin-like protofilaments. Presumably, BtubA/B were transferred from a eukaryotic cell by horizontal gene transfer because their high degree of similarity to eukaryotic genes is unique within the Prosthecobacter genome.
About this StructureAbout this Structure
2BTO is a Protein complex structure of sequences from Escherichia coli and Prosthecobacter dejongeii. Full crystallographic information is available from OCA.
ReferenceReference
Structure of bacterial tubulin BtubA/B: evidence for horizontal gene transfer., Schlieper D, Oliva MA, Andreu JM, Lowe J, Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9170-5. Epub 2005 Jun 20. PMID:15967998
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