2bs1: Difference between revisions
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|PDB= 2bs1 |SIZE=350|CAPTION= <scene name='initialview01'>2bs1</scene>, resolution 2.80Å | |PDB= 2bs1 |SIZE=350|CAPTION= <scene name='initialview01'>2bs1</scene>, resolution 2.80Å | ||
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bs1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bs1 OCA], [http://www.ebi.ac.uk/pdbsum/2bs1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bs1 RCSB]</span> | |||
}} | }} | ||
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[[Category: virus/viral protein/rna]] | [[Category: virus/viral protein/rna]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:10:53 2008'' | ||
Revision as of 02:10, 31 March 2008
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| , resolution 2.80Å | |||||||
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| Ligands: | , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
MS2 (N87AE89K MUTANT)- QBETA RNA HAIRPIN COMPLEX
OverviewOverview
Sequence-specific interactions between RNA stem-loops and coat protein (CP) subunits play vital roles in the life cycles of the RNA bacteriophages, e.g., by allowing translational repression of their replicase cistrons and tagging their own RNA genomes for encapsidation. The CPs of bacteriophages Qbeta and MS2 each discriminate in favor of their cognate translational operators, even in the presence of closely related operators from other phages in vivo. Discrete mutations within the MS2 CP have been shown to relax this discrimination in vitro. We have determined the structures of eight complexes between such mutants and both MS2 and Qbeta stem-loops with X-ray crystallography. In conjunction with previously determined in vivo repression data, the structures enable us to propose the molecular basis for the discrimination mechanism.
About this StructureAbout this Structure
2BS1 is a Protein complex structure of sequences from Enterobacterio phage ms2. Full crystallographic information is available from OCA.
ReferenceReference
Structural basis of RNA binding discrimination between bacteriophages Qbeta and MS2., Horn WT, Tars K, Grahn E, Helgstrand C, Baron AJ, Lago H, Adams CJ, Peabody DS, Phillips SE, Stonehouse NJ, Liljas L, Stockley PG, Structure. 2006 Mar;14(3):487-95. PMID:16531233
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Enterobacterio phage ms2
- Protein complex
- Adams, C J.
- Baron, A J.
- Grahn, E.
- Helgstrand, C.
- Horn, W T.
- Lago, H.
- Liljas, L.
- Peabody, D S.
- Phillips, S E.V.
- Stockley, P G.
- Stonehouse, N J.
- Tars, K.
- Capsid
- Complex (capsid protein-rna hairpin)
- Hairpin
- Icosahedral virus
- Levivirus
- Virus/viral protein/rna