6ble: Difference between revisions

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'''Unreleased structure'''


The entry 6ble is ON HOLD
==Crystal Structure of the Human CAMKK2B in complex with CP673451==
 
<StructureSection load='6ble' size='340' side='right' caption='[[6ble]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
Authors: Counago, R.M., de Souza, G.P., dos Reis, C.V., Drewry, D., Massirer, K.B., Arruda, P., Edwards, A.M., Structural Genomics Consortium (SGC), Elkins, J.M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6ble]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BLE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BLE FirstGlance]. <br>
Description: Crystal Structure of the Human CAMKK2B in complex with CP673451
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=34U:1-{2-[5-(2-METHOXYETHOXY)-1H-BENZIMIDAZOL-1-YL]QUINOLIN-8-YL}PIPERIDIN-4-AMINE'>34U</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ble FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ble OCA], [http://pdbe.org/6ble PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ble RCSB], [http://www.ebi.ac.uk/pdbsum/6ble PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ble ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/KKCC2_HUMAN KKCC2_HUMAN]] Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.<ref>PMID:11395482</ref> <ref>PMID:12935886</ref> <ref>PMID:9662074</ref> <ref>PMID:21957496</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Calcium/calmodulin-dependent protein kinase]]
[[Category: Arruda, P]]
[[Category: Counago, R M]]
[[Category: Drewry, D]]
[[Category: Drewry, D]]
[[Category: Edwards, A.M]]
[[Category: Edwards, A M]]
[[Category: Arruda, P]]
[[Category: Elkins, J M]]
[[Category: Massirer, K.B]]
[[Category: Massirer, K B]]
[[Category: Counago, R.M]]
[[Category: Reis, C V.dos]]
[[Category: Structural Genomics Consortium (Sgc), Elkins, J.M]]
[[Category: Structural genomic]]
[[Category: Dos Reis, C.V]]
[[Category: Souza, G P.de]]
[[Category: De Souza, G.P]]
[[Category: Protein kinase domain]]
[[Category: Sgc]]
[[Category: Transferase]]
[[Category: Transferase inhibitor complex]]

Revision as of 09:16, 29 November 2017

Crystal Structure of the Human CAMKK2B in complex with CP673451Crystal Structure of the Human CAMKK2B in complex with CP673451

Structural highlights

6ble is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Activity:Calcium/calmodulin-dependent protein kinase, with EC number 2.7.11.17
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[KKCC2_HUMAN] Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.[1] [2] [3] [4]

References

  1. ↑ Hsu LS, Chen GD, Lee LS, Chi CW, Cheng JF, Chen JY. Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity. J Biol Chem. 2001 Aug 17;276(33):31113-23. Epub 2001 Jun 6. PMID:11395482 doi:http://dx.doi.org/10.1074/jbc.M011720200
  2. ↑ Ishikawa Y, Tokumitsu H, Inuzuka H, Murata-Hori M, Hosoya H, Kobayashi R. Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. FEBS Lett. 2003 Aug 28;550(1-3):57-63. PMID:12935886
  3. ↑ Hsu LS, Tsou AP, Chi CW, Lee CH, Chen JY. Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase. J Biomed Sci. 1998;5(2):141-9. PMID:9662074
  4. ↑ Cao W, Sohail M, Liu G, Koumbadinga GA, Lobo VG, Xie J. Differential effects of PKA-controlled CaMKK2 variants on neuronal differentiation. RNA Biol. 2011 Nov-Dec;8(6):1061-72. doi: 10.4161/rna.8.6.16691. Epub 2011 Nov 1. PMID:21957496 doi:http://dx.doi.org/10.4161/rna.8.6.16691

6ble, resolution 1.90Å

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