2bop: Difference between revisions
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|PDB= 2bop |SIZE=350|CAPTION= <scene name='initialview01'>2bop</scene>, resolution 1.700Å | |PDB= 2bop |SIZE=350|CAPTION= <scene name='initialview01'>2bop</scene>, resolution 1.700Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=YB:YTTERBIUM (III) ION'>YB</scene> | |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bop OCA], [http://www.ebi.ac.uk/pdbsum/2bop PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bop RCSB]</span> | |||
}} | }} | ||
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[[Category: Laimins, L A.]] | [[Category: Laimins, L A.]] | ||
[[Category: Sigler, P B.]] | [[Category: Sigler, P B.]] | ||
[[Category: double helix]] | [[Category: double helix]] | ||
[[Category: protein-dna complex]] | [[Category: protein-dna complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:09:27 2008'' | ||
Revision as of 02:09, 31 March 2008
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| , resolution 1.700Å | |||||||
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| Ligands: | , , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE AT 1.7 ANGSTROMS OF THE BOVINE PAPILLOMAVIRUS-1 E2 DNA-BINDING DOMAIN BOUND TO ITS DNA TARGET
OverviewOverview
The dominant transcriptional regulator of the papillomaviruses, E2, binds to its specific DNA target through a previously unobserved dimeric antiparallel beta-barrel. The DNA is severely but smoothly bent over the barrel by the interaction of successive major grooves with a pair of symmetrically disposed alpha-helices. The specific interface is an 'interwoven' network of interactions where the identifying base pairs of the target contact more than one amino-acid side chain and the discriminating amino acids interact with more than one base pair.
About this StructureAbout this Structure
2BOP is a Single protein structure of sequence from Bovine papillomavirus type 1. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target., Hegde RS, Grossman SR, Laimins LA, Sigler PB, Nature. 1992 Oct 8;359(6395):505-12. PMID:1328886
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