Preprotein translocase: Difference between revisions

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'''Preprotein translocase''' (PPT) is responsible for the recognition and membrane translocation of preproteins.  PPT contains receptors and import motor<ref>PMID:9489663</ref>.  The translocase pathway contains:<br />
'''Preprotein translocase''' (PPT) is responsible for the recognition and membrane translocation of preproteins.  PPT contains receptors and import motor<ref>PMID:9489663</ref>.  The translocase pathway contains:<br />
*'''SecB''' - a chaperone protein<ref>PMID:9767586</ref> <br />
*'''SecB''' - a chaperone protein<ref>PMID:9767586</ref> <br />
*'''SecY, SecE, SecG''' an integral membrane complex<br />
*'''SecY, SecE, SecG''' or '''Sec61''' an integral membrane complex<br />
*'''SecD, SecF''' - proteins promoting the release of the mature peptide into the periplasm<br />
*'''SecD, SecF''' - proteins promoting the release of the mature peptide into the periplasm<br />
*'''SecA''' - an ATPase unit<ref>PMID:10617931</ref>.<br />
*'''SecA''' - an ATPase unit<ref>PMID:10617931</ref>.<br />

Revision as of 13:07, 27 November 2017

Function

Preprotein translocase (PPT) is responsible for the recognition and membrane translocation of preproteins. PPT contains receptors and import motor[1]. The translocase pathway contains:

  • SecB - a chaperone protein[2]
  • SecY, SecE, SecG or Sec61 an integral membrane complex
  • SecD, SecF - proteins promoting the release of the mature peptide into the periplasm
  • SecA - an ATPase unit[3].

For more details see SecA PBD motions.

Structure of preprotein translocase subunits SecY (grey), SecE (green), SecG (pink) (PDB entry 2yxr)

Drag the structure with the mouse to rotate

3D structures of preprotein translocase3D structures of preprotein translocase

Updated on 27-November-2017

ReferencesReferences

  1. ↑ Economou A. Bacterial preprotein translocase: mechanism and conformational dynamics of a processive enzyme. Mol Microbiol. 1998 Feb;27(3):511-8. PMID:9489663
  2. ↑ Fekkes P, de Wit JG, van der Wolk JP, Kimsey HH, Kumamoto CA, Driessen AJ. Preprotein transfer to the Escherichia coli translocase requires the co-operative binding of SecB and the signal sequence to SecA. Mol Microbiol. 1998 Sep;29(5):1179-90. PMID:9767586
  3. ↑ Schmidt MG, Kiser KB. SecA: the ubiquitous component of preprotein translocase in prokaryotes. Microbes Infect. 1999 Oct;1(12):993-1004. PMID:10617931

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Michal Harel, Alexander Berchansky
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