2b5n: Difference between revisions
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
|PDB= 2b5n |SIZE=350|CAPTION= <scene name='initialview01'>2b5n</scene>, resolution 2.8Å | |PDB= 2b5n |SIZE=350|CAPTION= <scene name='initialview01'>2b5n</scene>, resolution 2.8Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=IPA:ISOPROPYL ALCOHOL'>IPA</scene> | |LIGAND= <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[2b5l|2B5L]], [[2b5m|2B5M]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b5n OCA], [http://www.ebi.ac.uk/pdbsum/2b5n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b5n RCSB]</span> | |||
}} | }} | ||
| Line 27: | Line 30: | ||
[[Category: Zheng, N.]] | [[Category: Zheng, N.]] | ||
[[Category: Zhou, P.]] | [[Category: Zhou, P.]] | ||
[[Category: beta propeller]] | [[Category: beta propeller]] | ||
[[Category: damaged dna-binding protein]] | [[Category: damaged dna-binding protein]] | ||
| Line 33: | Line 35: | ||
[[Category: propeller cluster]] | [[Category: propeller cluster]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:01:48 2008'' | ||
Revision as of 02:01, 31 March 2008
| |||||||
| , resolution 2.8Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Related: | 2B5L, 2B5M
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of the DDB1 BPB Domain
OverviewOverview
The DDB1-Cul4A ubiquitin ligase complex promotes protein ubiquitination in diverse cellular functions and is reprogrammed by the V proteins of paramyxoviruses to degrade STATs and block interferon signaling. Here we report the crystal structures of DDB1 alone and in complex with the simian virus 5 V protein. The DDB1 structure reveals an intertwined three-propeller cluster, which contains two tightly coupled beta propellers with a large pocket in between and a third beta propeller flexibly attached on the side. The rigid double-propeller fold of DDB1 is targeted by the viral V protein, which inserts an entire helix into the double-propeller pocket, whereas the third propeller domain docks DDB1 to the N terminus of the Cul4A scaffold. Together, these results not only provide structural insights into how the virus hijacks the DDB1-Cul4A ubiquitin ligase but also establish a structural framework for understanding the multiple functions of DDB1 in the uniquely assembled cullin-RING E3 machinery.
About this StructureAbout this Structure
2B5N is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase., Li T, Chen X, Garbutt KC, Zhou P, Zheng N, Cell. 2006 Jan 13;124(1):105-17. PMID:16413485
Page seeded by OCA on Mon Mar 31 02:01:48 2008