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==High-resolution structure of the adenosine kinase from Mus musculus in complex with adenosine== | |||
<StructureSection load='5kb6' size='340' side='right' caption='[[5kb6]], [[Resolution|resolution]] 1.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5kb6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KB6 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kb5|5kb5]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Adk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosine_kinase Adenosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.20 2.7.1.20] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kb6 OCA], [http://pdbe.org/5kb6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kb6 RCSB], [http://www.ebi.ac.uk/pdbsum/5kb6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kb6 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ADK_MOUSE ADK_MOUSE]] ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Adenosine kinase]] | |||
[[Category: Lk3 transgenic mice]] | |||
[[Category: Franchini, K G]] | |||
[[Category: Murakami, M T]] | |||
[[Category: Neto, R M]] | |||
[[Category: Oliveira, R R]] | |||
[[Category: Polo, C C]] | |||
[[Category: Tonoli, C C.C]] | |||
[[Category: Transferase]] | |||
Revision as of 13:46, 16 November 2017
High-resolution structure of the adenosine kinase from Mus musculus in complex with adenosineHigh-resolution structure of the adenosine kinase from Mus musculus in complex with adenosine
Structural highlights
Function[ADK_MOUSE] ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. |
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