4r4r: Difference between revisions

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-'''Unreleased structure'''
-The entry 4r4r is ON HOLD  until Paper Publication
+==Crystal structure of chimeric beta-lactamase cTEM-19m at 1.2 angstrom resolution==
+<StructureSection load='4r4r' size='340' side='right' caption='[[4r4r]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
-Authors: Park, J., Gobeil, S., Pelletier, J.N., Berghuis, A.M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4r4r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R4R FirstGlance]. <br>
-Description: Crystal structure of chimeric beta-lactamase cTEM-19m at 1.2 angstrom resolution
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4id4|4id4]], [[4mez|4mez]]</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bla, blaT-3, blaT-4, blaT-5, blaT-6, pse4, carB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r4r OCA], [http://pdbe.org/4r4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r4r RCSB], [http://www.ebi.ac.uk/pdbsum/4r4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r4r ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX]] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
+__TOC__
+</StructureSection>
+[[Category: Beta-lactamase]]
+[[Category: Berghuis, A M]]
+[[Category: Gobeil, S]]
 [[Category: Park, J]]
-[[Category: Pelletier, J.N]]
+[[Category: Pelletier, J N]]
-[[Category: Gobeil, S]]
+[[Category: Hydrolase]]
-[[Category: Berghuis, A.M]]