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==X-Ray structure of a CypA-Alisporivir complex at 1.5 angstrom resolution== | |||
<StructureSection load='5hsv' size='340' side='right' caption='[[5hsv]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5hsv]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/African_green_monkey African green monkey]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HSV FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=66E:'>66E</scene>, <scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DAM:N-METHYL-ALPHA-BETA-DEHYDROALANINE'>DAM</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PPIA, CYPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9534 African green monkey])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hsv OCA], [http://pdbe.org/5hsv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hsv RCSB], [http://www.ebi.ac.uk/pdbsum/5hsv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hsv ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PPIA_CHLAE PPIA_CHLAE]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: African green monkey]] | |||
[[Category: Peptidylprolyl isomerase]] | |||
[[Category: Bouckaert, J]] | [[Category: Bouckaert, J]] | ||
[[Category: Dujardin, M]] | [[Category: Dujardin, M]] | ||
[[Category: Hanoulle, X]] | |||
[[Category: Rucktooa, P]] | [[Category: Rucktooa, P]] | ||
[[Category: | [[Category: Cyclophilin ppia csa-derivative non-immunosuppressive]] | ||
[[Category: Isomerase]] | |||
Revision as of 02:47, 16 November 2017
X-Ray structure of a CypA-Alisporivir complex at 1.5 angstrom resolutionX-Ray structure of a CypA-Alisporivir complex at 1.5 angstrom resolution
Structural highlights
Function[PPIA_CHLAE] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
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