4yi0: Difference between revisions
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==Structure of mouse importin a1 bound to Pom121NLS== | ==Structure of mouse importin a1 bound to Pom121NLS== | ||
<StructureSection load='4yi0' size='340' side='right' caption='[[4yi0]], [[Resolution|resolution]] 1.81Å' scene=''> | <StructureSection load='4yi0' size='340' side='right' caption='[[4yi0]], [[Resolution|resolution]] 1.81Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4yi0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YI0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YI0 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4yi0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YI0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YI0 FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3q5u|3q5u]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3q5u|3q5u]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yi0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yi0 OCA], [http://pdbe.org/4yi0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yi0 RCSB], [http://www.ebi.ac.uk/pdbsum/4yi0 PDBsum]</span></td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kpna2, Rch1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Pom121, Nup121 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yi0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yi0 OCA], [http://pdbe.org/4yi0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yi0 RCSB], [http://www.ebi.ac.uk/pdbsum/4yi0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yi0 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Buffalo rat]] | |||
[[Category: Lk3 transgenic mice]] | |||
[[Category: Cingolani, G]] | [[Category: Cingolani, G]] | ||
[[Category: Lokareddy, R K]] | [[Category: Lokareddy, R K]] | ||
Revision as of 18:48, 15 November 2017
Structure of mouse importin a1 bound to Pom121NLSStructure of mouse importin a1 bound to Pom121NLS
Structural highlights
Function[IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [PO121_RAT] Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). |
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