4pb1: Difference between revisions
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<StructureSection load='4pb1' size='340' side='right' caption='[[4pb1]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='4pb1' size='340' side='right' caption='[[4pb1]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4pb1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PB1 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4pb1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibch Vibch]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PB1 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RBV:1-(BETA-D-RIBOFURANOSYL)-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE'>RBV</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RBV:1-(BETA-D-RIBOFURANOSYL)-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE'>RBV</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tij|3tij]], [[4pd5|4pd5]], [[4pd7|4pd7]], [[4pb2|4pb2]], [[4pd8|4pd8]], [[4pd9|4pd9]], [[4pda|4pda]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tij|3tij]], [[4pd5|4pd5]], [[4pd7|4pd7]], [[4pb2|4pb2]], [[4pd8|4pd8]], [[4pd9|4pd9]], [[4pda|4pda]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VC_2352 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243277 VIBCH])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pb1 OCA], [http://pdbe.org/4pb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pb1 RCSB], [http://www.ebi.ac.uk/pdbsum/4pb1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pb1 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pb1 OCA], [http://pdbe.org/4pb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pb1 RCSB], [http://www.ebi.ac.uk/pdbsum/4pb1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pb1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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</div> | </div> | ||
<div class="pdbe-citations 4pb1" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4pb1" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Rebetol|Rebetol]] | |||
*[[Ribavirin|Ribavirin]] | |||
*[[Ribavirin (1-ò-D-ribofuranosyl-1H-1%2C2%2C4-triazole-3-carboxamide)|Ribavirin (1-ò-D-ribofuranosyl-1H-1%2C2%2C4-triazole-3-carboxamide)]] | |||
*[[Ribavirin1|Ribavirin1]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Vibch]] | |||
[[Category: Johnson, Z L]] | [[Category: Johnson, Z L]] | ||
[[Category: Lee, S Y]] | [[Category: Lee, S Y]] | ||
Revision as of 17:48, 15 November 2017
Structure of vcCNT-7C8C bound to ribavirinStructure of vcCNT-7C8C bound to ribavirin
Structural highlights
Publication Abstract from PubMedConcentrative nucleoside transporters (CNTs) are responsible for cellular entry of nucleosides, which serve as precursors to nucleic acids and act as signaling molecules. CNTs also play a crucial role in the uptake of nucleoside-derived drugs, including anticancer and antiviral agents. Understanding how CNTs recognize and import their substrates could not only lead to a better understanding of nucleoside-related biological processes but also the design of nucleoside-derived drugs that can better reach their targets. Here we present a combination of x-ray crystallographic and equilibrium-binding studies probing the molecular origins of nucleoside and nucleoside drug selectivity of a CNT from Vibrio cholerae. We then used this information in chemically modifying an anticancer drug so that is better transported by and selective for a single human CNT subtype. This work provides proof of principle for utilizing transporter structural and functional information for the design of compounds that enter cells more efficiently and selectively. Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.,Johnson ZL, Lee JH, Lee K, Lee M, Kwon DY, Hong J, Lee SY Elife. 2014 Jul 31:e03604. doi: 10.7554/eLife.03604. PMID:25082345[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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