4mlo: Difference between revisions
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<StructureSection load='4mlo' size='340' side='right' caption='[[4mlo]], [[Resolution|resolution]] 1.65Å' scene=''> | <StructureSection load='4mlo' size='340' side='right' caption='[[4mlo]], [[Resolution|resolution]] 1.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4mlo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MLO FirstGlance]. <br> | <table><tr><td colspan='2'>[[4mlo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MLO FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">toxT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=666 "Bacillo virgola del Koch" Trevisan 1884])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mlo OCA], [http://pdbe.org/4mlo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mlo RCSB], [http://www.ebi.ac.uk/pdbsum/4mlo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mlo ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mlo OCA], [http://pdbe.org/4mlo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mlo RCSB], [http://www.ebi.ac.uk/pdbsum/4mlo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mlo ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bacillo virgola del koch trevisan 1884]] | |||
[[Category: Battaile, K P]] | [[Category: Battaile, K P]] | ||
[[Category: Egan, S]] | [[Category: Egan, S]] | ||
Revision as of 12:53, 15 November 2017
1.65A resolution structure of ToxT from Vibrio cholerae (P21 Form)1.65A resolution structure of ToxT from Vibrio cholerae (P21 Form)
Structural highlights
Publication Abstract from PubMedToxT is an AraC-family transcriptional activator protein that controls the expression of key virulence factors in Vibrio cholerae, the causative agent of cholera. ToxT directly activates the expression of the genes that encode the toxin-coregulated pilus and cholera toxin, and also positively auto-regulates its own expression from the tcp promoter. The crystal structure of ToxT has previously been solved at 1.9 A resolution (PDB entry 3gbg). In this study, a crystal structure of ToxT at 1.65 A resolution with a similar overall structure to the previously determined structure is reported. However, there are distinct differences between the two structures, particularly in the region that extends from Asp101 to Glu110. This region, which can influence ToxT activity but was disordered in the previous structure, can be traced entirely in the current structure. 1.65 A resolution structure of the AraC-family transcriptional activator ToxT from Vibrio cholerae.,Li J, Wehmeyer G, Lovell S, Battaile KP, Egan SM Acta Crystallogr F Struct Biol Commun. 2016 Sep;72(Pt 9):726-31. doi:, 10.1107/S2053230X1601298X. Epub 2016 Aug 26. PMID:27599865[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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