4hsl: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 3: Line 3:
<StructureSection load='4hsl' size='340' side='right' caption='[[4hsl]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4hsl' size='340' side='right' caption='[[4hsl]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4hsl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HSL FirstGlance]. <br>
<table><tr><td colspan='2'>[[4hsl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cupmc Cupmc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HSL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3HA:3-HYDROXYANTHRANILIC+ACID'>3HA</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3HA:3-HYDROXYANTHRANILIC+ACID'>3HA</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hsj|4hsj]], [[4hsk|4hsk]], [[4hsm|4hsm]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hsj|4hsj]], [[4hsk|4hsk]], [[4hsm|4hsm]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cupriavidus metallidurans, nbaC, Rmet_5193 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=266264 CUPMC])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxyanthranilate_3,4-dioxygenase 3-hydroxyanthranilate 3,4-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.6 1.13.11.6] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxyanthranilate_3,4-dioxygenase 3-hydroxyanthranilate 3,4-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.6 1.13.11.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hsl OCA], [http://pdbe.org/4hsl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hsl RCSB], [http://www.ebi.ac.uk/pdbsum/4hsl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hsl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hsl OCA], [http://pdbe.org/4hsl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hsl RCSB], [http://www.ebi.ac.uk/pdbsum/4hsl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hsl ProSAT]</span></td></tr>
Line 16: Line 17:
</StructureSection>
</StructureSection>
[[Category: 3-hydroxyanthranilate 3,4-dioxygenase]]
[[Category: 3-hydroxyanthranilate 3,4-dioxygenase]]
[[Category: Cupmc]]
[[Category: Chen, L]]
[[Category: Chen, L]]
[[Category: Liu, A]]
[[Category: Liu, A]]

Revision as of 11:44, 15 November 2017

2.00 angstrom x-ray crystal structure of substrate-bound E110A 3-hydroxyanthranilate-3,4-dioxygenase from Cupriavidus metallidurans2.00 angstrom x-ray crystal structure of substrate-bound E110A 3-hydroxyanthranilate-3,4-dioxygenase from Cupriavidus metallidurans

Structural highlights

4hsl is a 1 chain structure with sequence from Cupmc. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Gene:Cupriavidus metallidurans, nbaC, Rmet_5193 (CUPMC)
Activity:3-hydroxyanthranilate 3,4-dioxygenase, with EC number 1.13.11.6
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[3HAO_RALME] Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.[1]

References

  1. ↑ Colabroy KL, Zhai H, Li T, Ge Y, Zhang Y, Liu A, Ealick SE, McLafferty FW, Begley TP. The mechanism of inactivation of 3-hydroxyanthranilate-3,4-dioxygenase by 4-chloro-3-hydroxyanthranilate. Biochemistry. 2005 May 31;44(21):7623-31. PMID:15909977 doi:http://dx.doi.org/10.1021/bi0473455

4hsl, resolution 2.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=4hsl&oldid=2811328"