3mlt: Difference between revisions

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<StructureSection load='3mlt' size='340' side='right' caption='[[3mlt]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
<StructureSection load='3mlt' size='340' side='right' caption='[[3mlt]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3mlt]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MLT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MLT FirstGlance]. <br>
<table><tr><td colspan='2'>[[3mlt]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MLT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MLT FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3mlr|3mlr]], [[3mls|3mls]], [[3mlu|3mlu]], [[3mlv|3mlv]], [[3mlw|3mlw]], [[3mlx|3mlx]], [[3mly|3mly]], [[3mlz|3mlz]]</td></tr>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3mlr|3mlr]], [[3mls|3mls]], [[3mlu|3mlu]], [[3mlv|3mlv]], [[3mlw|3mlw]], [[3mlx|3mlx]], [[3mly|3mly]], [[3mlz|3mlz]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mlt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mlt OCA], [http://pdbe.org/3mlt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mlt RCSB], [http://www.ebi.ac.uk/pdbsum/3mlt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mlt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mlt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mlt OCA], [http://pdbe.org/3mlt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mlt RCSB], [http://www.ebi.ac.uk/pdbsum/3mlt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mlt ProSAT]</span></td></tr>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Kong, X P]]
[[Category: Kong, X P]]
[[Category: Antibody-antigen interaction]]
[[Category: Antibody-antigen interaction]]

Revision as of 11:14, 8 November 2017

Crystal structure of anti-HIV-1 V3 Fab 2557 in complex with a UG1033 V3 peptideCrystal structure of anti-HIV-1 V3 Fab 2557 in complex with a UG1033 V3 peptide

Structural highlights

3mlt is a 10 chain structure with sequence from Homo sapiens and Human immunodeficiency virus 1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Binding of the third variable region (V3) of the HIV-1 envelope glycoprotein gp120 to the cell-surface coreceptors CCR5 or CXCR4 during viral entry suggests that there are conserved structural elements in this sequence-variable region. These conserved elements could serve as epitopes to be targeted by a vaccine against HIV-1. Here we perform a systematic structural analysis of representative human anti-V3 monoclonal antibodies in complex with V3 peptides, revealing that the crown of V3 has four conserved structural elements: an arch, a band, a hydrophobic core and the peptide backbone. These are either unaffected by or are subject to minimal sequence variation. As these regions are targeted by cross-clade neutralizing human antibodies, they provide a blueprint for the design of vaccine immunogens that could elicit broadly cross-reactive protective antibodies.

Conserved structural elements in the V3 crown of HIV-1 gp120.,Jiang X, Burke V, Totrov M, Williams C, Cardozo T, Gorny MK, Zolla-Pazner S, Kong XP Nat Struct Mol Biol. 2010 Aug;17(8):955-61. Epub 2010 Jul 11. PMID:20622876[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. Jiang X, Burke V, Totrov M, Williams C, Cardozo T, Gorny MK, Zolla-Pazner S, Kong XP. Conserved structural elements in the V3 crown of HIV-1 gp120. Nat Struct Mol Biol. 2010 Aug;17(8):955-61. Epub 2010 Jul 11. PMID:20622876 doi:10.1038/nsmb.1861

3mlt, resolution 2.49Å

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OCA