6ehm: Difference between revisions

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'''Unreleased structure'''


The entry 6ehm is ON HOLD
==Model of the Ebola virus nucleocapsid subunit from recombinant virus-like particles==
 
<StructureSection load='6ehm' size='340' side='right' caption='[[6ehm]], [[Resolution|resolution]] 7.30&Aring;' scene=''>
Authors: Wan, W., Kolesnikova, L., Clarke, M., Koehler, A., Noda, T., Becker, S., Briggs, J.A.G.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6ehm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EHM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EHM FirstGlance]. <br>
Description: Model of the Ebola virus nucleocapsid subunit from recombinant virus-like particles
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ehm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ehm OCA], [http://pdbe.org/6ehm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ehm RCSB], [http://www.ebi.ac.uk/pdbsum/6ehm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ehm ProSAT]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/NCAP_EBOZM NCAP_EBOZM]] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases. [[http://www.uniprot.org/uniprot/VP24_EBOZM VP24_EBOZM]] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.<ref>PMID:12191476</ref> <ref>PMID:12525613</ref> <ref>PMID:15220407</ref> <ref>PMID:17928350</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Becker, S]]
[[Category: Becker, S]]
[[Category: Noda, T]]
[[Category: Briggs, J A.G]]
[[Category: Clarke, M]]
[[Category: Clarke, M]]
[[Category: Wan, W]]
[[Category: Koehler, A]]
[[Category: Koehler, A]]
[[Category: Briggs, J.A.G]]
[[Category: Kolesnikova, L]]
[[Category: Kolesnikova, L]]
[[Category: Noda, T]]
[[Category: Wan, W]]
[[Category: Nucleocapsid]]
[[Category: Virus like particle]]
[[Category: Virus-like particle]]

Revision as of 10:56, 8 November 2017

Model of the Ebola virus nucleocapsid subunit from recombinant virus-like particlesModel of the Ebola virus nucleocapsid subunit from recombinant virus-like particles

Structural highlights

6ehm is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[NCAP_EBOZM] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases. [VP24_EBOZM] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.[1] [2] [3] [4]

References

  1. ↑ Huang Y, Xu L, Sun Y, Nabel GJ. The assembly of Ebola virus nucleocapsid requires virion-associated proteins 35 and 24 and posttranslational modification of nucleoprotein. Mol Cell. 2002 Aug;10(2):307-16. PMID:12191476
  2. ↑ Han Z, Boshra H, Sunyer JO, Zwiers SH, Paragas J, Harty RN. Biochemical and functional characterization of the Ebola virus VP24 protein: implications for a role in virus assembly and budding. J Virol. 2003 Feb;77(3):1793-800. PMID:12525613
  3. ↑ Licata JM, Johnson RF, Han Z, Harty RN. Contribution of ebola virus glycoprotein, nucleoprotein, and VP24 to budding of VP40 virus-like particles. J Virol. 2004 Jul;78(14):7344-51. PMID:15220407 doi:http://dx.doi.org/10.1128/JVI.78.14.7344-7351.2004
  4. ↑ Reid SP, Valmas C, Martinez O, Sanchez FM, Basler CF. Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1. J Virol. 2007 Dec;81(24):13469-77. Epub 2007 Oct 10. PMID:17928350 doi:http://dx.doi.org/10.1128/JVI.01097-07

6ehm, resolution 7.30Å

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