3fo8: Difference between revisions
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==Crystal structure of the bacteriophage T4 tail sheath protein, protease resistant fragment gp18PR== | ==Crystal structure of the bacteriophage T4 tail sheath protein, protease resistant fragment gp18PR== | ||
<StructureSection load='3fo8' size='340' side='right' caption='[[3fo8]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='3fo8' size='340' side='right' caption='[[3fo8]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3foa|3foa]], [[3foh|3foh]], [[3foi|3foi]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3foa|3foa]], [[3foh|3foh]], [[3foi|3foi]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">18, GB AAA32541.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 BPT4])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">18, GB AAA32541.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 BPT4])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fo8 OCA], [http://pdbe.org/3fo8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fo8 RCSB], [http://www.ebi.ac.uk/pdbsum/3fo8 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fo8 OCA], [http://pdbe.org/3fo8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fo8 RCSB], [http://www.ebi.ac.uk/pdbsum/3fo8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fo8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
Revision as of 09:46, 1 November 2017
Crystal structure of the bacteriophage T4 tail sheath protein, protease resistant fragment gp18PRCrystal structure of the bacteriophage T4 tail sheath protein, protease resistant fragment gp18PR
Structural highlights
Function[VG18_BPT4] The contractile tail of bacteriophage T4 consists of a contractile sheath, a tube and a baseplate. 144 protomers of Gp18, arranged in 24 annuli, form the contractile tail sheath which participates in viral DNA injection into host cytoplasm. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe contractile tail of bacteriophage T4 is a molecular machine that facilitates very high viral infection efficiency. Its major component is a tail sheath, which contracts during infection to less than half of its initial length. The sheath consists of 138 copies of the tail sheath protein, gene product (gp) 18, which surrounds the central non-contractile tail tube. The contraction of the sheath drives the tail tube through the outer membrane, creating a channel for the viral genome delivery. A crystal structure of about three quarters of gp18 has been determined and was fitted into cryo-electron microscopy reconstructions of the tail sheath before and after contraction. It was shown that during contraction, gp18 subunits slide over each other with no apparent change in their structure. The tail sheath structure of bacteriophage T4: a molecular machine for infecting bacteria.,Aksyuk AA, Leiman PG, Kurochkina LP, Shneider MM, Kostyuchenko VA, Mesyanzhinov VV, Rossmann MG EMBO J. 2009 Apr 8;28(7):821-9. Epub 2009 Feb 19. PMID:19229296[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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