1zll: Difference between revisions
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|GENE= PLN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= PLN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zll OCA], [http://www.ebi.ac.uk/pdbsum/1zll PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zll RCSB]</span> | |||
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==Disease== | ==Disease== | ||
Known | Known disease associated with this structure: Cardiomyopathy, dilated, 1P OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=172405 172405]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: super coil]] | [[Category: super coil]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:38:20 2008'' | ||
Revision as of 01:38, 31 March 2008
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| Gene: | PLN (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR Structure of Unphosphorylated Human Phospholamban Pentamer
OverviewOverview
Contraction and relaxation of heart muscle cells is regulated by cycling of calcium between cytoplasm and sarcoplasmic reticulum. Human phospholamban (PLN), expressed in the sarcoplasmic reticulum membrane as a 30-kDa homopentamer, controls cellular calcium levels by a mechanism that depends on its phosphorylation. Since PLN was discovered approximately 30 years ago, extensive studies have aimed to explain how it influences calcium pumps and to determine whether it acts as an ion channel. We have determined by solution NMR methods the atomic resolution structure of an unphosphorylated PLN pentamer in dodecylphosphocholine micelles. The unusual bellflower-like assembly is held together by leucine/isoleucine zipper motifs along the membrane-spanning helices. The structure reveals a channel-forming architecture that could allow passage of small ions. The central pore gradually widens toward the cytoplasmic end as the transmembrane helices twist around each other and bend outward. The dynamic N-terminal amphipathic helices point away from the membrane, perhaps facilitating recognition and inhibition of the calcium pump.
DiseaseDisease
Known disease associated with this structure: Cardiomyopathy, dilated, 1P OMIM:[172405]
About this StructureAbout this Structure
1ZLL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
The structure of phospholamban pentamer reveals a channel-like architecture in membranes., Oxenoid K, Chou JJ, Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10870-5. Epub 2005 Jul 25. PMID:16043693
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