1zle: Difference between revisions
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|PDB= 1zle |SIZE=350|CAPTION= <scene name='initialview01'>1zle</scene>, resolution 1.90Å | |PDB= 1zle |SIZE=350|CAPTION= <scene name='initialview01'>1zle</scene>, resolution 1.90Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=NI:NICKEL (II) ION'>NI</scene> | |LIGAND= <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1zld|1ZLD]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zle OCA], [http://www.ebi.ac.uk/pdbsum/1zle PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zle RCSB]</span> | |||
}} | }} | ||
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[[Category: Manning, V A.]] | [[Category: Manning, V A.]] | ||
[[Category: Sarma, G N.]] | [[Category: Sarma, G N.]] | ||
[[Category: | [[Category: beta-sandwich]] | ||
[[Category: | [[Category: rgd-motif]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:38:17 2008'' | ||
Revision as of 01:38, 31 March 2008
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| , resolution 1.90Å | |||||||
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| Ligands: | , | ||||||
| Related: | 1ZLD
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of a RGD-containing host-selective toxin: Pyrenophora tritici-repentis Ptr ToxA
OverviewOverview
Tan spot of wheat (Triticum aestivum), caused by the fungus Pyrenophora tritici-repentis, has significant agricultural and economic impact. Ptr ToxA (ToxA), the first discovered proteinaceous host-selective toxin, is produced by certain P. tritici-repentis races and is necessary and sufficient to cause cell death in sensitive wheat cultivars. We present here the high-resolution crystal structure of ToxA in two different crystal forms, providing four independent views of the protein. ToxA adopts a single-domain, beta-sandwich fold of novel topology. Mapping of the existing mutation data onto the structure supports the hypothesized importance of an Arg-Gly-Asp (RGD) and surrounding sequence. Its occurrence in a single, solvent-exposed loop in the protein suggests that it is directly involved in recognition events required for ToxA action. Furthermore, the ToxA structure reveals a surprising similarity with the classic mammalian RGD-containing domain, the fibronectin type III (FnIII) domain: the two topologies are related by circular permutation. The similar topologies and the positional conservation of the RGD-containing loop raises the possibility that ToxA is distantly related to mammalian FnIII proteins and that to gain entry it binds to an integrin-like receptor in the plant host.
About this StructureAbout this Structure
1ZLE is a Single protein structure of sequence from Pyrenophora tritici-repentis. Full crystallographic information is available from OCA.
ReferenceReference
Structure of Ptr ToxA: an RGD-containing host-selective toxin from Pyrenophora tritici-repentis., Sarma GN, Manning VA, Ciuffetti LM, Karplus PA, Plant Cell. 2005 Nov;17(11):3190-202. Epub 2005 Oct 7. PMID:16214901
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