3dax: Difference between revisions

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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dax ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dax ConSurf].
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==See Also==
*[[Cytochrome P450|Cytochrome P450]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Nadp]]
[[Category: Nadp]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Polymorphism]]
[[Category: Sgc]]
[[Category: Sgc]]
[[Category: Steroid metabolism]]
[[Category: Steroid metabolism]]

Revision as of 11:45, 25 October 2017

Crystal structure of human CYP7A1Crystal structure of human CYP7A1

Structural highlights

3dax is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Gene:CYP7A1, CYP7 (HUMAN)
Activity:Cholesterol 7-alpha-monooxygenase, with EC number 1.14.13.17
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CP7A1_HUMAN] Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. Li T, Chanda D, Zhang Y, Choi HS, Chiang JY. Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes. J Lipid Res. 2010 Apr;51(4):832-42. doi: 10.1194/jlr.M002782. Epub 2009 Oct 28. PMID:19965590 doi:http://dx.doi.org/10.1194/jlr.M002782

3dax, resolution 2.15Å

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OCA