3c6w: Difference between revisions

Revision as of 11:19, 25 October 2017

Crystal structure of the ING5 PHD finger in complex with H3K4me3 peptideCrystal structure of the ING5 PHD finger in complex with H3K4me3 peptide

Structural highlights

3c6w is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
NonStd Res:
Gene:	ING5 (HUMAN)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ING5_HUMAN] Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. Cancer Res. 2003 May 15;63(10):2373-8. PMID:12750254
↑ Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell. 2006 Jan 6;21(1):51-64. PMID:16387653 doi:10.1016/j.molcel.2005.12.007

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OCA

[1] Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. Cancer Res. 2003 May 15;63(10):2373-8. PMID:12750254

[2] Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell. 2006 Jan 6;21(1):51-64. PMID:16387653 doi:10.1016/j.molcel.2005.12.007

[1]

[2]

@@ Line 1: / Line 1: @@
 ==Crystal structure of the ING5 PHD finger in complex with H3K4me3 peptide==
 <StructureSection load='3c6w' size='340' side='right' caption='[[3c6w]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
@@ Line 6: / Line 7: @@
 <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ING5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c6w OCA], [http://pdbe.org/3c6w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3c6w RCSB], [http://www.ebi.ac.uk/pdbsum/3c6w PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c6w OCA], [http://pdbe.org/3c6w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3c6w RCSB], [http://www.ebi.ac.uk/pdbsum/3c6w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3c6w ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 29: / Line 30: @@
 [[Category: Kutateladze, T G]]
 [[Category: Pena, P V]]
+[[Category: Alternative splicing]]
 [[Category: Chromatin]]
 [[Category: Epigenetic]]
@@ Line 37: / Line 39: @@
 [[Category: Phd]]
 [[Category: Phosphoprotein]]
+[[Category: Zinc]]
 [[Category: Zinc-finger]]

3c6w: Difference between revisions

Revision as of 11:19, 25 October 2017

Crystal structure of the ING5 PHD finger in complex with H3K4me3 peptideCrystal structure of the ING5 PHD finger in complex with H3K4me3 peptide

Structural highlights

Function

Evolutionary Conservation

References

Contents

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3c6w: Difference between revisions

Revision as of 11:19, 25 October 2017

Crystal structure of the ING5 PHD finger in complex with H3K4me3 peptideCrystal structure of the ING5 PHD finger in complex with H3K4me3 peptide

Structural highlights

Function

Evolutionary Conservation

References

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