1z4y: Difference between revisions
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
|PDB= 1z4y |SIZE=350|CAPTION= <scene name='initialview01'>1z4y</scene>, resolution 2.600Å | |PDB= 1z4y |SIZE=350|CAPTION= <scene name='initialview01'>1z4y</scene>, resolution 2.600Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene> | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene> | ||
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span> | |||
|GENE= HN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11207 Simian virus 5]) | |GENE= HN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11207 Simian virus 5]) | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1z4v|1Z4V]], [[1z4x|1Z4X]], [[1z4w|1Z4W]], [[1z4z|1Z4Z]], [[1z50|1Z50]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4y OCA], [http://www.ebi.ac.uk/pdbsum/1z4y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z4y RCSB]</span> | |||
}} | }} | ||
| Line 29: | Line 32: | ||
[[Category: Wurzburg, B A.]] | [[Category: Wurzburg, B A.]] | ||
[[Category: Yuan, P.]] | [[Category: Yuan, P.]] | ||
[[Category: hemagglutinin,neuraminidase,fusion,tetramer]] | |||
[[Category: hemagglutinin | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:29:08 2008'' | ||
Revision as of 01:29, 31 March 2008
| |||||||
| , resolution 2.600Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Gene: | HN (Simian virus 5) | ||||||
| Activity: | Exo-alpha-sialidase, with EC number 3.2.1.18 | ||||||
| Related: | 1Z4V, 1Z4X, 1Z4W, 1Z4Z, 1Z50
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Parainfluenza Virus 5 (SV5) Hemagglutinin-Neuraminidase (HN) (pH 8.0)
OverviewOverview
The paramyxovirus hemagglutinin-neuraminidase (HN) functions in virus attachment to cells, cleavage of sialic acid from oligosaccharides, and stimulating membrane fusion during virus entry into cells. The structural basis for these diverse functions remains to be fully understood. We report the crystal structures of the parainfluenza virus 5 (SV5) HN and its complexes with sialic acid, the inhibitor DANA, and the receptor sialyllactose. SV5 HN shares common structural features with HN of Newcastle disease virus (NDV) and human parainfluenza 3 (HPIV3), but unlike the previously determined HN structures, the SV5 HN forms a tetramer in solution, which is thought to be the physiological oligomer. The sialyllactose complex reveals intact receptor within the active site, but no major conformational changes in the protein. The SV5 HN structures do not support previously proposed models for HN action in membrane fusion and suggest alternative mechanisms by which HN may promote virus entry into cells.
About this StructureAbout this Structure
1Z4Y is a Single protein structure of sequence from Simian virus 5. Full crystallographic information is available from OCA.
ReferenceReference
Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose., Yuan P, Thompson TB, Wurzburg BA, Paterson RG, Lamb RA, Jardetzky TS, Structure. 2005 May;13(5):803-15. PMID:15893670
Page seeded by OCA on Mon Mar 31 01:29:08 2008