1z3s: Difference between revisions
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|PDB= 1z3s |SIZE=350|CAPTION= <scene name='initialview01'>1z3s</scene>, resolution 2.35Å | |PDB= 1z3s |SIZE=350|CAPTION= <scene name='initialview01'>1z3s</scene>, resolution 2.35Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1z3u|1Z3U]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3s OCA], [http://www.ebi.ac.uk/pdbsum/1z3s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z3s RCSB]</span> | |||
}} | }} | ||
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[[Category: Nikolov, D B.]] | [[Category: Nikolov, D B.]] | ||
[[Category: Tzvetkova, D.]] | [[Category: Tzvetkova, D.]] | ||
[[Category: angiogenesis]] | [[Category: angiogenesis]] | ||
[[Category: tie2 binding]] | [[Category: tie2 binding]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:28:45 2008'' | ||
Revision as of 01:28, 31 March 2008
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| , resolution 2.35Å | |||||||
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| Ligands: | |||||||
| Related: | 1Z3U
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Angiopoietin-2 Receptor Binding Domain
OverviewOverview
The angiopoietins comprise a small class of secreted glycoproteins that play crucial roles in the maturation and maintenance of the mammalian vascular and lymphatic systems. They exert their effects through a member of the tyrosine kinase receptor family, Tie2. Angiopoietin/Tie2 signaling is unique among tyrosine kinase receptor-ligand systems in that distinct angiopoietin ligands, although highly homologous, can function as agonists or antagonists in a context-dependent manner. In an effort to understand this molecular dichotomy, we have crystallized and determined the 2.4 A crystal structure of the Angiopoietin-2 (Ang2) receptor binding region. The structure reveals a fibrinogen fold with a unique C-terminal P domain. Conservation analysis and structure-based mutagenesis identify a groove on the Ang2 molecular surface that mediates receptor recognition.
About this StructureAbout this Structure
1Z3S is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition., Barton WA, Tzvetkova D, Nikolov DB, Structure. 2005 May;13(5):825-32. PMID:15893672
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