Muscle LIM protein: Difference between revisions

Revision as of 19:35, 20 October 2017

Function

Muscle LIM protein (MLP) is a nuclear regulator of myogenic differentiation. It may act as an integrator of protein assembly of the actin-based cytoskeleton^[1]. For more details see Group:MUZIC:MLP and MLP.

Disease

Mutations in MLP are seen in cases of cardiomyopathy^[2].

Human muscle LIM protein 3 LiM domain complex with Zn+2 ions, NMR structure (PDB entry 1x4l)

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3D structures of muscle LIM protein3D structures of muscle LIM protein

Updated on 20-October-2017

1wyh, 2d8z – hLMP 2 LIM domain – human – NMR
1x4k, 1x4l, 2ehe - hLMP 3 LIM domain – NMR
1x63, 2cup, 2cur, 2egq - hLMP 1 LIM domain – NMR
2o10 - hLMP N terminal – NMR
2o13 - hLMP C terminal – NMR

ReferencesReferences

↑ Kong Y, Flick MJ, Kudla AJ, Konieczny SF. Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD. Mol Cell Biol. 1997 Aug;17(8):4750-60. PMID:9234731
↑ Geier C, Perrot A, Ozcelik C, Binner P, Counsell D, Hoffmann K, Pilz B, Martiniak Y, Gehmlich K, van der Ven PF, Furst DO, Vornwald A, von Hodenberg E, Nurnberg P, Scheffold T, Dietz R, Osterziel KJ. Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy. Circulation. 2003 Mar 18;107(10):1390-5. PMID:12642359

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

[1] Kong Y, Flick MJ, Kudla AJ, Konieczny SF. Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD. Mol Cell Biol. 1997 Aug;17(8):4750-60. PMID:9234731

[2] Geier C, Perrot A, Ozcelik C, Binner P, Counsell D, Hoffmann K, Pilz B, Martiniak Y, Gehmlich K, van der Ven PF, Furst DO, Vornwald A, von Hodenberg E, Nurnberg P, Scheffold T, Dietz R, Osterziel KJ. Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy. Circulation. 2003 Mar 18;107(10):1390-5. PMID:12642359

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-<StructureSection load='' size='350' side='right' caption='Human muscle LIM protein 3 LiM domain complex with Zn+2 ions, NMR structure (PDB entry [[1x4l]])' scene=''>
+<StructureSection load='1x4l' size='350' side='right' caption='Human muscle LIM protein 3 LiM domain complex with Zn+2 ions, NMR structure (PDB entry [[1x4l]])' scene=''>
 == Function ==
 '''Muscle LIM protein''' (MLP) is a nuclear regulator of myogenic differentiation.  It may act as an integrator of protein assembly of the actin-based cytoskeleton<ref>PMID:9234731</ref>.  For more details see [[Group:MUZIC:MLP]] and [[MLP]].