MAP kinase phosphatase: Difference between revisions
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<StructureSection load='1hzm' size='350' side='right' scene='' caption='MAP kinase phosphatase 3 (PDB code [[1hzm]])'> | |||
== Function == | == Function == | ||
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DUSP is implicated in the initiation and development of cancer<ref>PMID:18330678</ref>. | DUSP is implicated in the initiation and development of cancer<ref>PMID:18330678</ref>. | ||
</StructureSection> | |||
== 3D Structures of MAP kinase phosphatase == | == 3D Structures of MAP kinase phosphatase == | ||
Revision as of 17:09, 20 October 2017
FunctionMAP kinase phosphatase (MKP) or Dual specificity phosphatase (DUSP) are phosphatases which reverse the activation of MAP kinases by dephosphorylating tyrosine or threonine residues[1].
RelevanceDUSP is implicated in the initiation and development of cancer[2].
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3D Structures of MAP kinase phosphatase3D Structures of MAP kinase phosphatase
3ezz – hMKP-2 (mutant) or DUSP-HVH2 - human
2fys - hMKP-3 peptide or DUSP-5 +rMAP kinase – rat
1hzm - hMKP-3 or DUSP-5
1mkp - hMKP-3 or DUSP-5 (mutant)
3lj8 – hMKP-4
2ouc, 2oud, 1zzw - hMKP-5 or DUSP-10
2wgp – hMKP-6 or DUSP-14
2vsw - hMKP-7 or DUSP-16
1j4x – hDUSP-3 (mutant)+peptide
2g6z – hDUSP-5
2rf6, 2q05 – DUSP – Vaccinia virus
ReferencesReferences
- ↑ Boutros T, Chevet E, Metrakos P. Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer. Pharmacol Rev. 2008 Sep;60(3):261-310. doi: 10.1124/pr.107.00106. PMID:18922965 doi:http://dx.doi.org/10.1124/pr.107.00106
- ↑ Keyse SM. Dual-specificity MAP kinase phosphatases (MKPs) and cancer. Cancer Metastasis Rev. 2008 Jun;27(2):253-61. doi: 10.1007/s10555-008-9123-1. PMID:18330678 doi:http://dx.doi.org/10.1007/s10555-008-9123-1