5to5: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Structure of the TPR oligomerization domain== | |||
<StructureSection load='5to5' size='340' side='right' caption='[[5to5]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5to5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TO5 FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5to6|5to6]], [[5to7|5to7]]</td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5to5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5to5 OCA], [http://pdbe.org/5to5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5to5 RCSB], [http://www.ebi.ac.uk/pdbsum/5to5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5to5 ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/TPR_HUMAN TPR_HUMAN]] Papillary or follicular thyroid carcinoma. A chromosomal aberration involving TPR has been found in papillary thyroid carcinomas (PTCs). Intrachromosomal rearrangement that links the 5'-end of the TPR gene to the protein kinase domain of NTRK1 forms the fusion protein TRK-T1. TRK-T1 is a 55 kDa protein reacting with antibodies against the carboxy terminus of the NTRK1 protein.<ref>PMID:1532241</ref> Involved in tumorigenic rearrangements with the MET.<ref>PMID:2300559</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/TPR_HUMAN TPR_HUMAN]] Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:22253824 and PubMed:11952838). Plays also a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases.<ref>PMID:11952838</ref> <ref>PMID:15654337</ref> <ref>PMID:17897941</ref> <ref>PMID:18794356</ref> <ref>PMID:18981471</ref> <ref>PMID:19273613</ref> <ref>PMID:20133940</ref> <ref>PMID:20407419</ref> <ref>PMID:21613532</ref> <ref>PMID:22253824</ref> <ref>PMID:9864356</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Melcher, K]] | [[Category: Melcher, K]] | ||
[[Category: Pal, K]] | |||
[[Category: Xu, H E]] | |||
[[Category: Xu, Q]] | [[Category: Xu, Q]] | ||
[[Category: | [[Category: Zhou, X E]] | ||
[[Category: Cell cycle]] | |||
[[Category: Met]] | |||
[[Category: Oncogenic fusion kinase]] | |||
[[Category: Receptor tyrosine kinase]] | |||
[[Category: Tpr oligomerization domain]] | |||