Transfer RNA (tRNA): Difference between revisions
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==Structure== | ==Structure== | ||
The structure of most tRNA<ref>PMID:4601792</ref> is composed of <scene name='TRNA/Fullview_cartoon/1'>four helical stems</scene> arranged in a cloverleaf structure with four helical stems and an central four-way junction. The <scene name='TRNA/Acceptor_cartoon/1'>acceptor stem</scene> comprises the 5' and 3' ends of the molecule, the latter having an extension of four unpaired nucleotides, with a conserved terminal -CCA sequence at the 3' end. The anticodon stem, at the other end of the molecule is closed by the <scene name='TRNA/Anticodon_cartoon/2'>anticodon</scene> loop. The TΨC-stem and loop and the D-stem and loop form the core of the molecule. | The structure of most tRNA<ref>PMID:4601792</ref><ref>PMID:4612535</ref> is composed of <scene name='TRNA/Fullview_cartoon/1'>four helical stems</scene> arranged in a cloverleaf structure with four helical stems and an central four-way junction. The <scene name='TRNA/Acceptor_cartoon/1'>acceptor stem</scene> comprises the 5' and 3' ends of the molecule, the latter having an extension of four unpaired nucleotides, with a conserved terminal -CCA sequence at the 3' end. The anticodon stem, at the other end of the molecule is closed by the <scene name='TRNA/Anticodon_cartoon/2'>anticodon</scene> loop. The TΨC-stem and loop and the D-stem and loop form the core of the molecule. | ||
The overall shape of the molecule is that of a capital "L" letter. The two arms of the "L" are formed by the stacking of the acceptor and TΨC-stem on one side, and of the anticodon and D-stem on the other side. <scene name='TRNA/Tertiary_interactions/1'>Tertiary interactions</scene> between the TΨC- and D-loop form the corner of the L-shape and stabilise the structure. Non-Watson-Crick <scene name='43/433638/H_bonding/1'>hydrogen bonding</scene> is important in this core. | The overall shape of the molecule is that of a capital "L" letter. The two arms of the "L" are formed by the stacking of the acceptor and TΨC-stem on one side, and of the anticodon and D-stem on the other side. <scene name='TRNA/Tertiary_interactions/1'>Tertiary interactions</scene> between the TΨC- and D-loop form the corner of the L-shape and stabilise the structure. Non-Watson-Crick <scene name='43/433638/H_bonding/1'>hydrogen bonding</scene> is important in this core. | ||