Tubulin: Difference between revisions

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<StructureSection load='1z5w' size='400' side='right' caption='γ-tubulin complex with GTP and Mg+2 ion (green), [[1z5w]]' scene='43/430888/Cv/2' pspeed='8'>
<StructureSection load='' size='400' side='right' caption='γ-tubulin complex with GTP and Mg+2 ion (green), [[1z5w]]' scene='43/430888/Cv/2' pspeed='8'>
== Function ==
== Function ==


Revision as of 07:12, 16 October 2017

Function

Tubulin (TUB) is a constituent of microtubules in eukaryotes. Microtubules are assembled from dimers of α-tubulin (TUBA) and β-tubulin (TUBB) bound to GTP. See also Beta tubulin. γ-tubulin (TUBG) is part of the nucleation of microtubules[1]. Human TUB contains several numbered subtypes. FtsZ (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB[2]. See also Beta tubulin.

Relevance

The chemotherapeutic drug Taxol interacts with TUBB. See Molecular Playground/Taxol. TUBA and TUBB expression in polyps of invasive colon cancer is different from normal[3].

Disease

Mutations in TUBB underlie a large spectrum of neuronal migration disorders[4].

Structural highlights

γ-tubulin complex with GTP and Mg+2 ion (green), 1z5w

Drag the structure with the mouse to rotate

3D Structures of Tubulin3D Structures of Tubulin

Updated on 16-October-2017

ReferencesReferences

  1. ↑ Moritz M, Agard DA. Gamma-tubulin complexes and microtubule nucleation. Curr Opin Struct Biol. 2001 Apr;11(2):174-81. PMID:11297925
  2. ↑ Arjes HA, Lai B, Emelue E, Steinbach A, Levin PA. Mutations in the bacterial cell division protein FtsZ highlight the role of GTP binding and longitudinal subunit interactions in assembly and function. BMC Microbiol. 2015 Oct 13;15:209. doi: 10.1186/s12866-015-0544-z. PMID:26463348 doi:http://dx.doi.org/10.1186/s12866-015-0544-z
  3. ↑ Giarnieri E, De Francesco GP, Carico E, Midiri G, Amanti C, Giacomelli L, Tucci G, Gidaro S, Stroppa I, Gidaro G, Giovagnoli MR. Alpha- and beta-tubulin expression in rectal cancer development. Anticancer Res. 2005 Sep-Oct;25(5):3237-41. PMID:16101133
  4. ↑ Jaglin XH, Poirier K, Saillour Y, Buhler E, Tian G, Bahi-Buisson N, Fallet-Bianco C, Phan-Dinh-Tuy F, Kong XP, Bomont P, Castelnau-Ptakhine L, Odent S, Loget P, Kossorotoff M, Snoeck I, Plessis G, Parent P, Beldjord C, Cardoso C, Represa A, Flint J, Keays DA, Cowan NJ, Chelly J. Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria. Nat Genet. 2009 Jun;41(6):746-52. doi: 10.1038/ng.380. Epub 2009 May 24. PMID:19465910 doi:http://dx.doi.org/10.1038/ng.380

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