1ym5: Difference between revisions
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ym5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ym5 OCA], [http://www.ebi.ac.uk/pdbsum/1ym5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ym5 RCSB]</span> | |||
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:12:59 2008'' | ||
Revision as of 01:13, 31 March 2008
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily.
OverviewOverview
In the Pseudomonas bacterial genomes, the PhzF proteins are involved in the production of phenazine derivative antibiotic and antifungal compounds. The PhzF superfamily however also encompasses proteins in all genomes from bacteria to eukaryotes, for which no function has been assigned. We have determined the three dimensional crystal structure at 2.05 A resolution of YHI9, the yeast member of the PhzF family. YHI9 has a fold similar to bacterial diaminopimelate epimerase, revealing a bimodular structure with an internal symmetry. Residue conservation identifies a putative active site at the interface between the two domains. Evolution of this protein by gene duplication, gene fusion and domain swapping from an ancestral gene containing the "hot dog" fold, identifies the protein as a "kinked double hot dog" fold.
About this StructureAbout this Structure
1YM5 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily., Liger D, Quevillon-Cheruel S, Sorel I, Bremang M, Blondeau K, Aboulfath I, Janin J, van Tilbeurgh H, Leulliot N, Proteins. 2005 Sep 1;60(4):778-86. PMID:16021630
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Saccharomyces cerevisiae
- Single protein
- Aboulfath, I.
- Blondeau, K.
- Bremang, M.
- Janin, J.
- Leulliot, N.
- Liger, D.
- Quevillon-Cheruel, S.
- Sorel, I.
- Tilbeurgh, H Van.
- YSG, Paris-Sud Yeast Structural Genomics.
- Double hot-dog
- Paris-sud yeast structural genomic
- Phzf enzyme superfamily
- Structural genomic
- Ysg