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==Crystal structure of a complex between bovine chymotrypsin and ecotin== | ==Crystal structure of a complex between bovine chymotrypsin and ecotin== | ||
<StructureSection load='1n8o' size='340' side='right' caption='[[1n8o]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='1n8o' size='340' side='right' caption='[[1n8o]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1n8o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1n8o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin] and [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N8O FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1azz|1azz]], [[1ecy|1ecy]], [[1fi8|1fi8]], [[1id5|1id5]], [[1ifg|1ifg]], [[1slu|1slu]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1azz|1azz]], [[1ecy|1ecy]], [[1fi8|1fi8]], [[1id5|1id5]], [[1ifg|1ifg]], [[1slu|1slu]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8o OCA], [http://pdbe.org/1n8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n8o RCSB], [http://www.ebi.ac.uk/pdbsum/1n8o PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8o OCA], [http://pdbe.org/1n8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1n8o RCSB], [http://www.ebi.ac.uk/pdbsum/1n8o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1n8o ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n8o ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n8o ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Bovin]] | ||
[[Category: Chymotrypsin]] | [[Category: Chymotrypsin]] | ||
[[Category: | [[Category: Ecoli]] | ||
[[Category: Cambillau, C]] | [[Category: Cambillau, C]] | ||
[[Category: Lauwereys, M]] | [[Category: Lauwereys, M]] | ||
[[Category: Spinelli, S]] | [[Category: Spinelli, S]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Revision as of 14:21, 12 October 2017
Crystal structure of a complex between bovine chymotrypsin and ecotinCrystal structure of a complex between bovine chymotrypsin and ecotin
Structural highlights
Function[ECOT_ECOLI] General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear to be correlated with a particular protease specificity.[HAMAP-Rule:MF_00706] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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