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==Crystal Structure of the EMAP II-like Cytokine Released from human tyrosyl-tRNA Synthetase== | ==Crystal Structure of the EMAP II-like Cytokine Released from human tyrosyl-tRNA Synthetase== | ||
<StructureSection load='1ntg' size='340' side='right' caption='[[1ntg]], [[Resolution|resolution]] 2.21Å' scene=''> | <StructureSection load='1ntg' size='340' side='right' caption='[[1ntg]], [[Resolution|resolution]] 2.21Å' scene=''> | ||
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ntg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntg OCA], [http://pdbe.org/1ntg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ntg RCSB], [http://www.ebi.ac.uk/pdbsum/1ntg PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ntg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntg OCA], [http://pdbe.org/1ntg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ntg RCSB], [http://www.ebi.ac.uk/pdbsum/1ntg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ntg ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
Revision as of 14:14, 12 October 2017
Crystal Structure of the EMAP II-like Cytokine Released from human tyrosyl-tRNA SynthetaseCrystal Structure of the EMAP II-like Cytokine Released from human tyrosyl-tRNA Synthetase
Structural highlights
Disease[SYYC_HUMAN] Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC) [MIM:608323]. CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.[1] Function[SYYC_HUMAN] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. References
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