1sum: Difference between revisions
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==Crystal structure of a hypothetical protein at 2.0 A resolution== | ==Crystal structure of a hypothetical protein at 2.0 A resolution== | ||
<StructureSection load='1sum' size='340' side='right' caption='[[1sum]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='1sum' size='340' side='right' caption='[[1sum]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
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<table><tr><td colspan='2'>[[1sum]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SUM FirstGlance]. <br> | <table><tr><td colspan='2'>[[1sum]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SUM FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PO3:PHOSPHITE+ION'>PO3</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PO3:PHOSPHITE+ION'>PO3</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sum OCA], [http://pdbe.org/1sum PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sum RCSB], [http://www.ebi.ac.uk/pdbsum/1sum PDBsum], [http://www.topsan.org/Proteins/BSGC/1sum TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sum OCA], [http://pdbe.org/1sum PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sum RCSB], [http://www.ebi.ac.uk/pdbsum/1sum PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sum ProSAT], [http://www.topsan.org/Proteins/BSGC/1sum TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
Revision as of 13:58, 12 October 2017
Crystal structure of a hypothetical protein at 2.0 A resolutionCrystal structure of a hypothetical protein at 2.0 A resolution
Structural highlights
Function[PHOU2_THEMA] Plays a role in the regulation of phosphate uptake (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedPhoU proteins are known to play a role in the regulation of phosphate uptake. In Thermotoga maritima, two PhoU homologues have been identified bioinformatically. Here we report the crystal structure of one of the PhoU homologues at 2.0 A resolution. The structure of the PhoU protein homologue contains a highly symmetric new structural fold composed of two repeats of a three-helix bundle. The structure unexpectedly revealed a trinuclear and a tetranuclear iron cluster that were found to be bound on the surface. Each of the two multinuclear iron clusters is coordinated by a conserved E(D)XXXD motif pair. Our structure reveals a new class of metalloprotein containing multinuclear iron clusters. The possible functional implication based on the structure are discussed. Crystal structure of a PhoU protein homologue: a new class of metalloprotein containing multinuclear iron clusters.,Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH J Biol Chem. 2005 Apr 22;280(16):15960-6. Epub 2005 Feb 16. PMID:15716271[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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