Stimulator of interferon genes: Difference between revisions

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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	<StructureSection load='~~4loh~~' size='450' side='right' caption='Structure of human STING CTD complex with c-GMP-AMP (PDB entry [[4loh]])' scene='57/573101/Cv/1'>		<StructureSection load='' size='450' side='right' caption='Structure of human STING CTD complex with c-GMP-AMP (PDB entry [[4loh]])' scene='57/573101/Cv/1'>

	'''Stimulator of interferon genes''' (STING) induces production of type I interferon when cells are infected by viruses, mycobacteria and intracellular parasites. STING recognizes and binds cyclic-di-GMP produced by bacteria and cyclic-GMP AMP (cGAMP) produced by viruses. The C-terminal domain (CTD) (residues 139-379 in human) of STING binds cyclic-di-GMP. STING is a facilitator of innate immune signaling<ref>PMID:26980676</ref>.		'''Stimulator of interferon genes''' (STING) induces production of type I interferon when cells are infected by viruses, mycobacteria and intracellular parasites. STING recognizes and binds cyclic-di-GMP produced by bacteria and cyclic-GMP AMP (cGAMP) produced by viruses. The C-terminal domain (CTD) (residues 139-379 in human) of STING binds cyclic-di-GMP. STING is a facilitator of innate immune signaling<ref>PMID:26980676</ref>.