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==Crystal structure of Candida antarctica Lipase B with active Ser105 modified with a phosphonate inhibitor== | |||
<StructureSection load='5gv5' size='340' side='right' caption='[[5gv5]], [[Resolution|resolution]] 2.89Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5gv5]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GV5 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSW:[(1S)-2-(methoxycarbonylamino)-1-phenyl-ethoxy]-propyl-phosphinic+acid'>MSW</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gv5 OCA], [http://pdbe.org/5gv5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gv5 RCSB], [http://www.ebi.ac.uk/pdbsum/5gv5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gv5 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/LIPB_PSEA2 LIPB_PSEA2]] Hydrolysis of triglycerides. Is very stereospecific both in hydrolysis and in organic synthesis and has a potentially important application in glucolipid synthesis. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Triacylglycerol lipase]] | |||
[[Category: Lee, H]] | [[Category: Lee, H]] | ||
[[Category: Park, S | [[Category: Park, S Y]] | ||
[[Category: Cal-b]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Inhibitor]] | |||
[[Category: Lipase]] | |||
[[Category: Phosphonate]] | |||
Revision as of 08:15, 6 October 2017
Crystal structure of Candida antarctica Lipase B with active Ser105 modified with a phosphonate inhibitorCrystal structure of Candida antarctica Lipase B with active Ser105 modified with a phosphonate inhibitor
Structural highlights
Function[LIPB_PSEA2] Hydrolysis of triglycerides. Is very stereospecific both in hydrolysis and in organic synthesis and has a potentially important application in glucolipid synthesis. |
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