1ido: Difference between revisions

Revision as of 17:34, 5 November 2007

I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND

OverviewOverview

We have determined the high resolution crystal structure of the A domain, from the alpha chain of integrin CR3. The domain adopts a classic, alpha/beta "Rossmann" fold and contains an unusual Mg2+ coordination site, at its surface. One of the coordinating ligands is the glutamate side, chain from another A domain molecule. We suggest that this site represents, a general metal ion-dependent adhesion site (MIDAS) for binding protein, ligands. We further propose that the beta subunits of integrins contain a, MIDAS motif within a modified A domain. Our crystal structure will allow, reliable models to be built for other members of the A domain superfamily, and should facilitate development of novel adhesion modulatory drugs.

About this StructureAbout this Structure

1IDO is a Single protein structure of sequence from Homo sapiens with MG as ligand. Structure known Active Site: MG. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)., Lee JO, Rieu P, Arnaout MA, Liddington R, Cell. 1995 Feb 24;80(4):631-8. PMID:7867070

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	[[Category: integrin]]		[[Category: integrin]]

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