5t72: Difference between revisions

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-'''Unreleased structure'''
-The entry 5t72 is ON HOLD  until Paper Publication
+==Human carboanhydrase F131C_C206S double mutant in complex with 2==
+<StructureSection load='5t72' size='340' side='right' caption='[[5t72]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
-Authors: DuBay, K.H., Iwan, K., Osorio-Planes, L., Geissler, P., Groll, M., Trauner, D., Broichhagen, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5t72]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T72 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T72 FirstGlance]. <br>
-Description: Human carboanhydrase F131C_C206S double mutant in complex with 2
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4WA:4-[(E)-(4-AMINOPHENYL)DIAZENYL]BENZENESULFONAMIDE'>4WA</scene>, <scene name='pdbligand=HGB:4-(HYDROXYMERCURY)BENZOIC+ACID'>HGB</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vva|2vva]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t72 OCA], [http://pdbe.org/5t72 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t72 RCSB], [http://www.ebi.ac.uk/pdbsum/5t72 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t72 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Carbonate dehydratase]]
 [[Category: Broichhagen, J]]
+[[Category: DuBay, K H]]
+[[Category: Geissler, P]]
+[[Category: Groll, M]]
 [[Category: Iwan, K]]
 [[Category: Osorio-Planes, L]]
 [[Category: Trauner, D]]
-[[Category: Dubay, K.H]]
+[[Category: Azobenzene]]
-[[Category: Groll, M]]
+[[Category: Carbonic anhydrase]]
-[[Category: Geissler, P]]
+[[Category: Computational screening]]
+[[Category: Photochromic tethered ligand]]
+[[Category: Photopharmacology]]
+[[Category: Transferase]]